› 1o7v

X-ray diffraction
1.9Å resolution

High resolution structure of Siglec-7

Released:
DOI: 10.2210/pdb1o7v/pdb
PDB entry 1o7v coloured by chain, front view.
PDB entry 1o7v coloured by chain, side view.
PDB entry 1o7v coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
High resolution crystal structures of Siglec-7. Insights into ligand specificity in the Siglec family.
Alphey MS, Attrill H, Crocker PR, van Aalten DM
J Biol Chem 278 3372-7 (2003)
PMID: 12438315

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195116 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Sialic acid-binding Ig-like lectin 7 Chain: A
Molecule details ›
Chain: A
Length: 127 amino acids
Theoretical weight: 14.66 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q9Y286 (Residues: 18-144; Coverage: 28%)
Gene names: AIRM1, SIGLEC7
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P43212
Unit cell:
a: 40.049Å b: 40.049Å c: 140.769Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.21 0.258
Expression system: Cricetulus griseus

Quick links

Citations

18 review citations

Siglecs and their roles in the immune system.
Crocker et al. (2007)
17 more

10 mentions without citation

Structural and functional diversity of the lectin repertoire in teleost fish: relevance to innate and adaptive immunity.
Vasta et al. (2011)
9 more