PDBe 1nzz

X-ray diffraction
2.45Å resolution

Human mitochondrial aldehyde dehydrogenase complexed with NADH in the presence of low Mg2+

Source organism: Homo sapiens
Primary publication:
Coenzyme isomerization is integral to catalysis in aldehyde dehydrogenase.
Biochemistry 42 7100-9 (2003)
PMID: 12795606

Function and Biology Details

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Aldehyde dehydrogenase, mitochondrial Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 500 amino acids
Theoretical weight: 54.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
  • Canonical: P05091 (Residues: 18-517; Coverage: 97%)
Gene names: ALDH2, ALDM
Sequence domains: Aldehyde dehydrogenase family
Structure domains:

Ligands and Environments

Cofactor: Ligand NAI 8 x NAI
2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P212121
Unit cell:
a: 141.307Å b: 150.897Å c: 177.031Å
α: 90° β: 90° γ: 90°
R R work R free
0.22 0.215 0.248
Expression system: Escherichia coli BL21