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The high resolution structures of RmlC from Streptococcus suis in complex with dTDP-D-xylose

Source organism: Streptococcus suis
Biochemical function: isomerase activity
Biological process: extracellular polysaccharide biosynthetic process
Cellular component: cytosol

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EC 5.1.3.13: dTDP-4-dehydrorhamnose 3,5-epimerase

Reaction catalysed:
dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose
Systematic name:
dTDP-4-dehydro-6-deoxy-alpha-D-glucose 3,5-epimerase
Alternative Name(s):
  • TDP-4-keto-L-rhamnose-3,5-epimerase
  • TDP-4-ketorhamnose 3,5-epimerase
  • Thymidine diphospho-4-ketorhamnose 3,5-epimerase
  • dTDP-4-dehydro-6-deoxy-D-glucose 3,5-epimerase
  • dTDP-4-keto-6-deoxyglucose 3,5-epimerase
  • dTDP-L-rhamnose synthetase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00908
Domain description: dTDP-4-dehydrorhamnose 3,5-epimerase
Occurring in:
  1. dTDP-4-dehydrorhamnose 3,5-epimerase
The deposited structure of PDB entry 1nzc contains 4 copies of Pfam domain PF00908 (dTDP-4-dehydrorhamnose 3,5-epimerase) in dTDP-4-dehydrorhamnose 3,5-epimerase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000888
Domain description: dTDP-4-dehydrorhamnose 3,5-epimerase-like
Occurring in:
  1. dTDP-4-dehydrorhamnose 3,5-epimerase
IPR011051
Domain description: RmlC-like cupin domain superfamily
Occurring in:
  1. dTDP-4-dehydrorhamnose 3,5-epimerase
IPR014710
Domain description: RmlC-like jelly roll fold
Occurring in:
  1. dTDP-4-dehydrorhamnose 3,5-epimerase

Structure domain

CATH CATH domain
2.60.120.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Jelly Rolls
Homology: Jelly Rolls
Occurring in:
  1. dTDP-4-dehydrorhamnose 3,5-epimerase
The deposited structure of PDB entry 1nzc contains 4 copies of CATH domain 2.60.120.10 (Jelly Rolls) in dTDP-4-dehydrorhamnose 3,5-epimerase. Showing 1 copy in chain A.
SCOP SCOP annotation
51183
Class: All beta proteins
Fold: Double-stranded beta-helix
Superfamily: RmlC-like cupins
Occurring in:
  1. dTDP-4-dehydrorhamnose 3,5-epimerase
The deposited structure of PDB entry 1nzc contains 4 copies of SCOP domain 51183 (dTDP-sugar isomerase) in dTDP-4-dehydrorhamnose 3,5-epimerase. Showing 1 copy in chain A.

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