Function and Biology

Crystal structure of wild type Cre recombinase-loxP synapse

Source organism: Punavirus P1
Biochemical function: DNA binding
Biological process: DNA integration
Cellular component: not assigned

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00589
Domain description: Phage integrase family
Occurring in:
  1. Recombinase cre
The deposited structure of PDB entry 1nzb contains 4 copies of Pfam domain PF00589 (Phage integrase family) in Recombinase cre. Showing 1 copy in chain E [auth A].

InterPro InterPro annotations
IPR002104
Domain description: Integrase, catalytic domain
Occurring in:
  1. Recombinase cre
IPR013762
Domain description: Integrase-like, catalytic domain superfamily
Occurring in:
  1. Recombinase cre
IPR011010
Domain description: DNA breaking-rejoining enzyme, catalytic core
Occurring in:
  1. Recombinase cre
IPR010998
Domain description: Integrase/recombinase, N-terminal
Occurring in:
  1. Recombinase cre
IPR044068
Domain description: Core-binding (CB) domain
Occurring in:
  1. Recombinase cre

Structure domains

CATH CATH domains
1.10.443.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: hpI Integrase; Chain A
Homology: Intergrase catalytic core
Occurring in:
  1. Recombinase cre
The deposited structure of PDB entry 1nzb contains 4 copies of CATH domain 1.10.443.10 (hpI Integrase; Chain A) in Recombinase cre. Showing 1 copy in chain E [auth A].
1.10.150.130
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: DNA polymerase; domain 1
Homology: DNA polymerase; domain 1
Occurring in:
  1. Recombinase cre
The deposited structure of PDB entry 1nzb contains 4 copies of CATH domain 1.10.150.130 (DNA polymerase; domain 1) in Recombinase cre. Showing 1 copy in chain E [auth A].
SCOP SCOP annotations
56350
Class: Alpha and beta proteins (a+b)
Fold: DNA breaking-rejoining enzymes
Superfamily: DNA breaking-rejoining enzymes
Occurring in:
  1. Recombinase cre
The deposited structure of PDB entry 1nzb contains 4 copies of SCOP domain 56350 (Lambda integrase-like, catalytic core) in Recombinase cre. Showing 1 copy in chain E [auth A].
47824
Class: All alpha proteins
Fold: SAM domain-like
Superfamily: lambda integrase-like, N-terminal domain
Occurring in:
  1. Recombinase cre
The deposited structure of PDB entry 1nzb contains 4 copies of SCOP domain 47824 (lambda integrase-like, N-terminal domain) in Recombinase cre. Showing 1 copy in chain E [auth A].