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X-ray diffraction
3.1Å resolution

Crystal Structure of Activin A Bound to the ECD of ActRIIB

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Activin receptor type-2B Chains: A, C
Molecule details ›
Chains: A, C
Length: 105 amino acids
Theoretical weight: 12.34 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P38445 (Residues: 19-119; Coverage: null%)
Gene names: Actriib, Acvr2b
Structure domains: CD59
Inhibin beta A chain Chains: B, D
Molecule details ›
Chains: B, D
Length: 116 amino acids
Theoretical weight: 12.99 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P08476 (Residues: 311-426; Coverage: null%)
Gene name: INHBA
Sequence domains: Transforming growth factor beta like domain
Structure domains: Cystine-knot cytokines

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 5ID-B
Spacegroup: P41212
Unit cell:
a: 141.33Å b: 141.33Å c: 46.021Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.269 0.268 0.291
Expression systems:
  • Spodoptera frugiperda
  • Cricetulus griseus