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N5-glutamine methyltransferase, HemK

Source organism: Thermotoga maritima
Biochemical function: protein-(glutamine-N5) methyltransferase activity
Biological process: methylation
Cellular component: not assigned

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EC 2.1.1.297: Peptide chain release factor N(5)-glutamine methyltransferase

Reaction catalysed:
S-adenosyl-L-methionine + [peptide chain release factor 1 or 2]-L-glutamine = S-adenosyl-L-homocysteine + [peptide chain release factor 1 or 2]-N(5)-methyl-L-glutamine
Systematic name:
S-adenosyl-L-methionine:[peptide chain release factor 1 or 2]-L-glutamine (N(5)-glutamine)-methyltransferase
Alternative Name(s):
  • HemK
  • N(5)-glutamine MTase
  • N(5)-glutamine S-adenosyl-L-methionine dependent methyltransferase
  • PrmC

GO terms

Sequence families

Pfam Protein families (Pfam)
PF05175
Domain description: Methyltransferase small domain
Occurring in:
  1. Release factor glutamine methyltransferase
The deposited structure of PDB entry 1nv8 contains 2 copies of Pfam domain PF05175 (Methyltransferase small domain) in Release factor glutamine methyltransferase. Showing 1 copy in chain A.

PF17827
Domain description: PrmC N-terminal domain
Occurring in:
  1. Release factor glutamine methyltransferase
The deposited structure of PDB entry 1nv8 contains 2 copies of Pfam domain PF17827 (PrmC N-terminal domain) in Release factor glutamine methyltransferase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR029063
Domain description: S-adenosyl-L-methionine-dependent methyltransferase superfamily
Occurring in:
  1. Release factor glutamine methyltransferase
IPR019874
Domain description: Protein-(glutamine-N5) methyltransferase, release factor-specific
Occurring in:
  1. Release factor glutamine methyltransferase
IPR002052
Domain description: DNA methylase, N-6 adenine-specific, conserved site
Occurring in:
  1. Release factor glutamine methyltransferase
IPR007848
Domain description: Methyltransferase small domain
Occurring in:
  1. Release factor glutamine methyltransferase
IPR004556
Domain description: Methyltransferase HemK-like
Occurring in:
  1. Release factor glutamine methyltransferase
IPR040758
Domain description: Release factor glutamine methyltransferase, N-terminal domain
Occurring in:
  1. Release factor glutamine methyltransferase

Structure domains

CATH CATH domains
3.40.50.150
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Vaccinia Virus protein VP39
Occurring in:
  1. Release factor glutamine methyltransferase
The deposited structure of PDB entry 1nv8 contains 2 copies of CATH domain 3.40.50.150 (Rossmann fold) in Release factor glutamine methyltransferase. Showing 1 copy in chain A.
1.10.8.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Helicase, Ruva Protein; domain 3
Homology: DNA helicase RuvA subunit, C-terminal domain
Occurring in:
  1. Release factor glutamine methyltransferase
The deposited structure of PDB entry 1nv8 contains 2 copies of CATH domain 1.10.8.10 (Helicase, Ruva Protein; domain 3) in Release factor glutamine methyltransferase. Showing 1 copy in chain A.
SCOP SCOP annotation
89743
Class: Alpha and beta proteins (a/b)
Fold: S-adenosyl-L-methionine-dependent methyltransferases
Superfamily: S-adenosyl-L-methionine-dependent methyltransferases
Occurring in:
  1. Release factor glutamine methyltransferase
The deposited structure of PDB entry 1nv8 contains 2 copies of SCOP domain 89743 (N5-glutamine methyltransferase, HemK) in Release factor glutamine methyltransferase. Showing 1 copy in chain A.

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