1nur

X-ray diffraction
2.15Å resolution

CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC NMN/NaMN ADENYLYLTRANSFERASE

Released:

Function and Biology Details

Reactions catalysed:
ATP + nicotinamide ribonucleotide = diphosphate + NAD(+)
ATP + beta-nicotinate-D-ribonucleotide = diphosphate + deamido-NAD(+)
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 252 amino acids
Theoretical weight: 28.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96T66 (Residues: 1-252; Coverage: 100%)
Gene names: FKSG76, NMNAT3
Sequence domains: Cytidylyltransferase-like
Structure domains: HUPs

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P43212
Unit cell:
a: 79.355Å b: 79.355Å c: 146.24Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.196 0.246
Expression system: Escherichia coli