X-ray diffraction
2.7Å resolution

Crystal structure of the CUB1-EGF-CUB2 region of MASP2


Function and Biology Details

Reaction catalysed:
Selective cleavage after Arg(223) in complement component C2 (-Ser-Leu-Gly-Arg-|-Lys-Ile-Gln-Ile) and after Arg(76) in complement component C4 (-Gly-Leu-Gln-Arg-|-Ala-Leu-Glu-Ile)
Biochemical function:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Mannan-binding lectin serine protease 2 A chain Chains: A, G
Molecule details ›
Chains: A, G
Length: 286 amino acids
Theoretical weight: 32.56 KDa
Source organism: Rattus norvegicus
Expression system: Cricetulus griseus
  • Canonical: Q9JJS8 (Residues: 20-299; Coverage: 42%)
Gene name: Masp2
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: P21
Unit cell:
a: 70.411Å b: 103.901Å c: 70.484Å
α: 90° β: 119.93° γ: 90°
R R work R free
0.248 0.248 0.283
Expression system: Cricetulus griseus