1nsk

X-ray diffraction
2.8Å resolution

THE CRYSTAL STRUCTURE OF A HUMAN NUCLEOSIDE DIPHOSPHATE KINASE, NM23-H2

Released:
Source organism: Homo sapiens

Function and Biology Details

Reactions catalysed:
ATP + protein L-histidine = ADP + protein N-phospho-L-histidine
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nucleoside diphosphate kinase B Chains: L, N, O, R, T, U
Molecule details ›
Chains: L, N, O, R, T, U
Length: 152 amino acids
Theoretical weight: 17.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P22392 (Residues: 1-152; Coverage: 100%)
Gene names: NM23B, NME2
Sequence domains: Nucleoside diphosphate kinase
Structure domains: Nucleoside diphosphate kinase-like domain

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 118.67Å b: 118.8Å c: 90.19Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.249 0.249 0.294
Expression system: Escherichia coli