1nr6

X-ray diffraction
2.1Å resolution

MICROSOMAL CYTOCHROME P450 2C5/3LVDH COMPLEX WITH DICLOFENAC

Released:

Function and Biology Details

Reaction catalysed:
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O
Biochemical function:
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytochrome P450 2C5 Chain: A
Molecule details ›
Chain: A
Length: 473 amino acids
Theoretical weight: 53.88 KDa
Source organism: Oryctolagus cuniculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P00179 (Residues: 27-487; Coverage: 95%)
Gene name: CYP2C5
Sequence domains: Cytochrome P450
Structure domains: Cytochrome P450

Ligands and Environments


Cofactor: Ligand HEM 1 x HEM
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: I222
Unit cell:
a: 73.94Å b: 130.02Å c: 172.78Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.231 0.231 0.268
Expression system: Escherichia coli