› 1nko

X-ray diffraction
1.45Å resolution

Energetic and structural basis of sialylated oligosaccharide recognition by the natural killer cell inhibitory receptor p75/AIRM1 or Siglec-7

Released:
DOI: 10.2210/pdb1nko/pdb
PDB entry 1nko coloured by chain, front view.
PDB entry 1nko coloured by chain, side view.
PDB entry 1nko coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the saccharide-binding domain of the human natural killer cell inhibitory receptor p75/AIRM1.
Dimasi N, Moretta A, Moretta L, Biassoni R, Mariuzza RA
Acta Crystallogr D Biol Crystallogr 60 401-3 (2004)
PMID: 14747738

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195116 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sialic acid-binding Ig-like lectin 7 Chain: A
Molecule details ›
Chain: A
Length: 132 amino acids
Theoretical weight: 15.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y286 (Residues: 19-150; Coverage: 29%)
Gene names: AIRM1, SIGLEC7
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: P21
Unit cell:
a: 32.461Å b: 49.715Å c: 39.787Å
α: 90° β: 113.08° γ: 90°
R-values:
R R work R free
0.277 0.277 0.301
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Siglecs--the major subfamily of I-type lectins.
Varki et al. (2006)
1 more

13 mentions without citation

Sialic Acids and Their Influence on Human NK Cell Function.
Rosenstock et al. (2021)
12 more