› › Structure analysis

THYMIDYLATE SYNTHASE WITH 2'-DEOXYCYTIDINE 5'-MONOPHOSPHATE (DCMP)

X-ray diffraction
2.3Å resolution
PDB entry 1nje coloured by chain, front view.
PDB entry 1nje coloured by chain, side view.
PDB entry 1nje coloured by chain, top view.
Source organism: Lacticaseibacillus casei
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: Thymidylate synthase
hide full assembly name
Multimeric state: homo dimer
Accessible surface area: 25499.01 Å2
Buried surface area: 5843.83 Å2
Dissociation area: 2,385.08 Å2
Dissociation energy (ΔGdiss): 28.09 kcal/mol
Dissociation entropy (TΔSdiss): 14.11 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-132544

Macromolecules

Thymidylate synthase
Chain: A
Length: 316 amino acids
Theoretical weight: 36.63 KDa
Source organism: Lacticaseibacillus casei
Expression system: Escherichia coli
UniProt:
  • Canonical: P00469 (Residues: 1-316; Coverage: 100%)
Gene name: thyA
Pfam: Thymidylate synthase
InterPro:
CATH: Thymidylate synthase/dCMP hydroxymethylase domain
SCOP: Thymidylate synthase/dCMP hydroxymethylase
Thymidylate synthase in PDB entry 1nje, assembly 1, front view.
Thymidylate synthase in PDB entry 1nje, assembly 1, side view.
Thymidylate synthase in PDB entry 1nje, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links