› 1nhz

X-ray diffraction
2.3Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-137440 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glucocorticoid receptor Chain: A
Molecule details ›
Chain: A
Length: 280 amino acids
Theoretical weight: 32.16 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P04150 (Residues: 500-777; Coverage: 36%)
Gene names: GRL, NR3C1
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

2 bound ligands:
Ligand 486 1 x 486
Ligand HEZ 3 x HEZ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P21212
Unit cell:
a: 74.859Å b: 109.764Å c: 39.261Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.204 0.276
Expression system: Spodoptera frugiperda

Quick links

Citations

44 review citations

Antiinflammatory action of glucocorticoids--new mechanisms for old drugs.
Rhen et al. (2005)
43 more

31 mentions without citation

The Biologist's Guide to the Glucocorticoid Receptor's Structure.
Deploey et al. (2023)
30 more