Function and Biology

STRUCTURAL BASIS OF THE 70-KILODALTON HEAT SHOCK COGNATE PROTEIN ATP HYDROLYTIC ACTIVITY, II. STRUCTURE OF THE ACTIVE SITE WITH ADP OR ATP BOUND TO WILD TYPE AND MUTANT ATPASE FRAGMENT

Source organism: Bos taurus
Biochemical function: ATP binding
Biological process: not assigned
Cellular component: not assigned

EC 3.6.4.10: Non-chaperonin molecular chaperone ATPase

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Systematic name:
ATP phosphohydrolase (polypeptide-polymerizing)
Alternative Name(s):
  • Molecular chaperone Hsc70 ATPase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

InterPro InterPro annotation
IPR013126
Domain description: Heat shock protein 70 family
Occurring in:
  1. Heat shock cognate 71 kDa protein

Structure domains

CATH CATH domains
3.30.420.40
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Nucleotidyltransferase; domain 5
Homology: Nucleotidyltransferase; domain 5
Occurring in:
  1. Heat shock cognate 71 kDa protein
3 copies of CATH domain 3.30.420.40 (Nucleotidyltransferase; domain 5) in Heat shock cognate 71 kDa protein in PDB 1ngj.
3.30.30.30
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Defensin A-like
Homology: Defensin A-like
Occurring in:
  1. Heat shock cognate 71 kDa protein
1 copy of CATH domain 3.30.30.30 (Defensin A-like) in Heat shock cognate 71 kDa protein in PDB 1ngj.
3.90.640.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Actin; Chain A, domain 4
Homology: Actin; Chain A, domain 4
Occurring in:
  1. Heat shock cognate 71 kDa protein
1 copy of CATH domain 3.90.640.10 (Actin; Chain A, domain 4) in Heat shock cognate 71 kDa protein in PDB 1ngj.
SCOP SCOP annotation
53068
Class: Alpha and beta proteins (a/b)
Fold: Ribonuclease H-like motif
Superfamily: Actin-like ATPase domain
Occurring in:
  1. Heat shock cognate 71 kDa protein
2 copies of SCOP domain 53068 (Actin/HSP70) in Heat shock cognate 71 kDa protein in PDB 1ngj.