1nfk

X-ray diffraction
2.3Å resolution

STRUCTURE OF THE NUCLEAR FACTOR KAPPA-B (NF-KB) P50 HOMODIMER

Released:
Source organism: Mus musculus
Primary publication:
Structure of NF-kappa B p50 homodimer bound to a kappa B site.
Nature 373 303-10 (1995)
PMID: 7530332

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
Nuclear factor NF-kappa-B p50 subunit Chains: A, B
Molecule details ›
Chains: A, B
Length: 325 amino acids
Theoretical weight: 36.6 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P25799 (Residues: 39-363; Coverage: 34%)
Gene name: Nfkb1
Sequence domains:
Structure domains:
DNA (5'-D(*TP*GP*GP*GP*AP*AP*TP*TP*CP*CP*C)-3') Chains: C, D
Molecule details ›
Chains: C, D
Length: 11 nucleotides
Theoretical weight: 3.35 KDa
Source organism: Mus musculus
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: C2
Unit cell:
a: 84.2Å b: 132.1Å c: 80.1Å
α: 90° β: 93.1° γ: 90°
R-values:
R R work R free
0.23 0.23 0.34
Expression system: Not provided