› 1nd1

X-ray diffraction
1.93Å resolution

Amino acid sequence and crystal structure of BaP1, a metalloproteinase from Bothrops asper snake venom that exerts multiple tissue-damaging activities.

Released:
DOI: 10.2210/pdb1nd1/pdb
PDB 1nd1 coloured by chain and viewed from the front.
PDB 1nd1 coloured by chain and viewed from the side.
PDB 1nd1 coloured by chain and viewed from the top.
Source organism: Bothrops asper
Primary publication:
Amino acid sequence and crystal structure of BaP1, a metalloproteinase from Bothrops asper snake venom that exerts multiple tissue-damaging activities.
Watanabe L, Shannon JD, Valente RH, Rucavado A, Alape-Girón A, Kamiguti AS, Theakston RD, Fox JW, Gutiérrez JM, Arni RK
Protein Sci. 12 2273-81 (2003)
PMID: 14500885

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Snake venom metalloproteinase BaP1 Chain: A
Molecule details ›
Chain: A
Length: 202 amino acids
Theoretical weight: 22.75 KDa
Source organism: Bothrops asper
UniProt:
  • Canonical: P83512 (Residues: 193-394; Coverage: 52%)
Sequence domains: Reprolysin (M12B) family zinc metalloprotease
Structure domains: Collagenase (Catalytic Domain)

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
1 modified residue:
Ligand PCA 1 x PCA

Experiments and Validation Details

Entry percentile scores
X-ray source: LNLS BEAMLINE D03B-MX1
Spacegroup: P212121
Unit cell:
a: 38.425Å b: 60.364Å c: 86.257Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.191 0.191 0.216

Quick links

Citations

8 review citations

Bleeding and Thrombosis: Insights into Pathophysiology of Bothrops Venom-Related Hemostasis Disorders.
Larréché et al. (2021)
7 more

7 mentions without citation

Mesenchymal Stromal Cell-Based Therapies as Promising Treatments for Muscle Regeneration After Snakebite Envenoming.
Sanchez-Castro et al. (2020)
6 more