1n8s

X-ray diffraction
3.04Å resolution

Structure of the pancreatic lipase-colipase complex

Released:
Source organisms:
Primary publication:
Structure of the pancreatic lipase-procolipase complex.
Nature 359 159-62 (1992)
PMID: 1522902

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Pancreatic triacylglycerol lipase Chain: A
Molecule details ›
Chain: A
Length: 449 amino acids
Theoretical weight: 49.57 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P16233 (Residues: 17-465; Coverage: 100%)
Gene name: PNLIP
Sequence domains:
Structure domains:
Colipase Chain: C
Molecule details ›
Chain: C
Length: 95 amino acids
Theoretical weight: 10.35 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: P02703 (Residues: 18-110; Coverage: 98%)
Gene name: CLPS
Sequence domains:
Structure domains: Lipase, subunit A

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LURE BEAMLINE DW32
Spacegroup: P3221
Unit cell:
a: 80.3Å b: 80.3Å c: 251Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.23 0.23 0.29