Reviews - 1n7d mentioned but not cited (7)
- Wnt signaling in triple-negative breast cancer. Pohl SG, Brook N, Agostino M, Arfuso F, Kumar AP, Dharmarajan A. Oncogenesis 6 e310 (2017)
- The use of polyoxometalates in protein crystallography - An attempt to widen a well-known bottleneck. Bijelic A, Rompel A. Coord Chem Rev 299 22-38 (2015)
- Versatility in ligand recognition by LDL receptor family proteins: advances and frontiers. Blacklow SC. Curr Opin Struct Biol 17 419-426 (2007)
- The biology of PCSK9 from the endoplasmic reticulum to lysosomes: new and emerging therapeutics to control low-density lipoprotein cholesterol. Poirier S, Mayer G. Drug Des Devel Ther 7 1135-1148 (2013)
- Structural Insights into Reelin Function: Present and Future. Ranaivoson FM, von Daake S, Comoletti D. Front Cell Neurosci 10 137 (2016)
- Endoplasmic reticulum quality control in lipoprotein metabolism. Koerner CM, Roberts BS, Neher SB. Mol Cell Endocrinol 498 110547 (2019)
- Predictive Modeling and Structure Analysis of Genetic Variants in Familial Hypercholesterolemia: Implications for Diagnosis and Protein Interaction Studies. Larrea-Sebal A, Jebari-Benslaiman S, Galicia-Garcia U, Jose-Urteaga AS, Uribe KB, Benito-Vicente A, Martín C. Curr Atheroscler Rep 25 839-859 (2023)
Articles - 1n7d mentioned but not cited (42)
- Mutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q. Toomes C, Bottomley HM, Jackson RM, Towns KV, Scott S, Mackey DA, Craig JE, Jiang L, Yang Z, Trembath R, Woodruff G, Gregory-Evans CY, Gregory-Evans K, Parker MJ, Black GC, Downey LM, Zhang K, Inglehearn CF. Am J Hum Genet 74 721-730 (2004)
- Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH. Lo Surdo P, Bottomley MJ, Calzetta A, Settembre EC, Cirillo A, Pandit S, Ni YG, Hubbard B, Sitlani A, Carfí A. EMBO Rep 12 1300-1305 (2011)
- Structural basis of agrin-LRP4-MuSK signaling. Zong Y, Zhang B, Gu S, Lee K, Zhou J, Yao G, Figueiredo D, Perry K, Mei L, Jin R. Genes Dev 26 247-258 (2012)
- Model of human low-density lipoprotein and bound receptor based on cryoEM. Ren G, Rudenko G, Ludtke SJ, Deisenhofer J, Chiu W, Pownall HJ. Proc Natl Acad Sci U S A 107 1059-1064 (2010)
- Analysis of the frequency and spectrum of mutations recognised to cause familial hypercholesterolaemia in routine clinical practice in a UK specialist hospital lipid clinic. Futema M, Whittall RA, Kiley A, Steel LK, Cooper JA, Badmus E, Leigh SE, Karpe F, Neil HA, Simon Broome Register Group, Humphries SE. Atherosclerosis 229 161-168 (2013)
- Cholera- and anthrax-like toxins are among several new ADP-ribosyltransferases. Fieldhouse RJ, Turgeon Z, White D, Merrill AR. PLoS Comput Biol 6 e1001029 (2010)
- Mechanism of LDL binding and release probed by structure-based mutagenesis of the LDL receptor. Huang S, Henry L, Ho YK, Pownall HJ, Rudenko G. J Lipid Res 51 297-308 (2010)
- Gentamicin binds to the megalin receptor as a competitive inhibitor using the common ligand binding motif of complement type repeats: insight from the nmr structure of the 10th complement type repeat domain alone and in complex with gentamicin. Dagil R, O'Shea C, Nykjær A, Bonvin AM, Kragelund BB. J Biol Chem 288 4424-4435 (2013)
- Decoding of lipoprotein-receptor interactions: properties of ligand binding modules governing interactions with apolipoprotein E. Guttman M, Prieto JH, Croy JE, Komives EA. Biochemistry 49 1207-1216 (2010)
- PhoX: An IMAC-Enrichable Cross-Linking Reagent. Steigenberger B, Pieters RJ, Heck AJR, Scheltema RA. ACS Cent Sci 5 1514-1522 (2019)
- Advantages and versatility of fluorescence-based methodology to characterize the functionality of LDLR and class mutation assignment. Etxebarria A, Benito-Vicente A, Alves AC, Ostolaza H, Bourbon M, Martin C. PLoS One 9 e112677 (2014)
- Regulation of tau internalization, degradation, and seeding by LRP1 reveals multiple pathways for tau catabolism. Cooper JM, Lathuiliere A, Migliorini M, Arai AL, Wani MM, Dujardin S, Muratoglu SC, Hyman BT, Strickland DK. J Biol Chem 296 100715 (2021)
- Role of an intramolecular contact on lipoprotein uptake by the LDL receptor. Zhao Z, Michaely P. Biochim Biophys Acta 1811 397-408 (2011)
- Giardia lamblia low-density lipoprotein receptor-related protein is involved in selective lipoprotein endocytosis and parasite replication. Rivero MR, Miras SL, Quiroga R, Rópolo AS, Touz MC. Mol Microbiol 79 1204-1219 (2011)
- Polyoxometalates: more than a phasing tool in protein crystallography. Bijelic A, Rompel A. ChemTexts 4 10 (2018)
- Structural basis for ligand capture and release by the endocytic receptor ApoER2. Hirai H, Yasui N, Yamashita K, Tabata S, Yamamoto M, Takagi J, Nogi T. EMBO Rep 18 982-999 (2017)
- The Proprotein Convertase Subtilisin/Kexin Type 9-resistant R410S Low Density Lipoprotein Receptor Mutation: A NOVEL MECHANISM CAUSING FAMILIAL HYPERCHOLESTEROLEMIA. Susan-Resiga D, Girard E, Kiss RS, Essalmani R, Hamelin J, Asselin MC, Awan Z, Butkinaree C, Fleury A, Soldera A, Dory YL, Baass A, Seidah NG. J Biol Chem 292 1573-1590 (2017)
- Atherogenic effect of Arecoline: A computational study. Choudhury MD, Chetia P, Choudhury KD, Talukdar AD, Datta-Choudhari M. Bioinformation 8 229-232 (2012)
- Interaction between SCO-spondin and low density lipoproteins from embryonic cerebrospinal fluid modulates their roles in early neurogenesis. Vera A, Recabal A, Saldivia N, Stanic K, Torrejón M, Montecinos H, Caprile T. Front Neuroanat 9 72 (2015)
- Exploring the complete mutational space of the LDL receptor LA5 domain using molecular dynamics: linking SNPs with disease phenotypes in familial hypercholesterolemia. Angarica VE, Orozco M, Sancho J. Hum Mol Genet 25 1233-1246 (2016)
- A Novel Pathogenic HSPG2 Mutation in Schwartz-Jampel Syndrome. Lin PY, Hung JH, Hsu CK, Chang YT, Sun YT. Front Neurol 12 632336 (2021)
- Mapping the binding region on the low density lipoprotein receptor for blood coagulation factor VIII. Kurasawa JH, Shestopal SA, Karnaukhova E, Struble EB, Lee TK, Sarafanov AG. J Biol Chem 288 22033-22041 (2013)
- New horizons for lipoprotein receptors: communication by β-propellers. Andersen OM, Dagil R, Kragelund BB. J Lipid Res 54 2763-2774 (2013)
- Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) Promotes Macrophage Activation via LDL Receptor-Independent Mechanisms. Katsuki S, K Jha P, Lupieri A, Nakano T, Passos LSA, Rogers MA, Becker-Greene D, Le TD, Decano JL, Ho Lee L, Guimaraes GC, Abdelhamid I, Halu A, Muscoloni A, V Cannistraci C, Higashi H, Zhang H, Vromman A, Libby P, Keith Ozaki C, Sharma A, Singh SA, Aikawa E, Aikawa M. Circ Res 131 873-889 (2022)
- In Silico Insights into Protein-protein Interaction Disruptive Mutations in the PCSK9-LDLR complex. Martin WR, Lightstone FC, Cheng F. Int J Mol Sci 21 (2020)
- Molecular Dynamics Simulation Reveals Exposed Residues in the Ligand-Binding Domain of the Low-Density Lipoprotein Receptor that Interacts with Vesicular Stomatitis Virus-G Envelope. Al-Allaf FA, Abduljaleel Z, Taher MM, Abdellatif AAH, Athar M, Bogari NM, Al-Ahdal MN, Al-Mohanna F, Al-Hassnan ZN, Alzabeedi KHY, Banssir TM, Bouazzaoui A. Viruses 11 (2019)
- Molecular characterization of the lipophorin receptor in the crustacean ectoparasite Lepeophtheirus salmonis. Khan MT, Dalvin S, Waheed Q, Nilsen F, Male R. PLoS One 13 e0195783 (2018)
- Molecular modeling of LDLR aids interpretation of genomic variants. Klee EW, Zimmermann MT. J Mol Med (Berl) 97 533-540 (2019)
- Near-membrane ensemble elongation in the proline-rich LRP6 intracellular domain may explain the mysterious initiation of the Wnt signaling pathway. Liu C, Yao M, Hogue CW. BMC Bioinformatics 12 Suppl 13 S13 (2011)
- Structural Biology Helps Interpret Variants of Uncertain Significance in Genes Causing Endocrine and Metabolic Disorders. Ittisoponpisan S, David A. J Endocr Soc 2 842-854 (2018)
- Structural analysis of human NHLRC2, mutations of which are associated with FINCA disease. Biterova E, Ignatyev A, Uusimaa J, Hinttala R, Ruddock LW. PLoS One 13 e0202391 (2018)
- The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins. Chakraborty S, Rendón-Ramírez A, Ásgeirsson B, Dutta M, Ghosh AS, Oda M, Venkatramani R, Rao BJ, Dandekar AM, Goñi FM. F1000Res 2 286 (2013)
- Differences in Recycling of Apolipoprotein E3 and E4-LDL Receptor Complexes-A Mechanistic Hypothesis. Kim M, Bezprozvanny I. Int J Mol Sci 22 (2021)
- Expanding the genetic spectrum for Chinese familial hypercholesterolemia population with six genetic mutations identified using a next-generation sequencing-based laboratory-developed screening test. Jingxin S, Shitong C. Mol Genet Genomic Med 10 e2070 (2022)
- Nanoscape, a data-driven 3D real-time interactive virtual cell environment. Kadir SR, Lilja A, Gunn N, Strong C, Hughes RT, Bailey BJ, Rae J, Parton RG, McGhee J. Elife 10 e64047 (2021)
- Whole exome sequencing confirms the clinical diagnosis of Marfan syndrome combined with X-linked hypophosphatemia. Sheng X, Chen X, Lei B, Chen R, Wang H, Zhang F, Rong W, Ha R, Liu Y, Zhao F, Yang P, Zhao C. J Transl Med 13 179 (2015)
- Assessing the genetic burden of familial hypercholesterolemia in a large middle eastern biobank. Gandhi GD, Aamer W, Krishnamoorthy N, Syed N, Aliyev E, Al-Maraghi A, Kohailan M, Alenbawi J, Elanbari M, Qatar Genome Program Research Consortium (QGPRC), Mifsud B, Mokrab Y, Khalil CA, Fakhro KA. J Transl Med 20 502 (2022)
- Deep generative models of LDLR protein structure to predict variant pathogenicity. James JK, Norland K, Johar AS, Kullo IJ. J Lipid Res 64 100455 (2023)
- Identification of roles for H264, H306, H439, and H635 in acid-dependent lipoprotein release by the LDL receptor. Dong H, Zhao Z, LeBrun DG, Michaely P. J Lipid Res 58 364-374 (2017)
- research-article Joint genotypic and phenotypic outcome modeling improves base editing variant effect quantification. Ryu J, Barkal S, Yu T, Jankowiak M, Zhou Y, Francoeur M, Phan QV, Li Z, Tognon M, Brown L, Love MI, Lettre G, Ascher DB, Cassa CA, Sherwood RI, Pinello L. medRxiv 2023.09.08.23295253 (2023)
- Low Density Lipoprotein Receptor Variants in the Beta-Propeller Subdomain and Their Functional Impact. Dušková L, Nohelová L, Loja T, Fialová J, Zapletalová P, Réblová K, Tichý L, Freiberger T, Fajkusová L. Front Genet 11 691 (2020)
- Structures of LRP2 reveal a molecular machine for endocytosis. Beenken A, Cerutti G, Brasch J, Guo Y, Sheng Z, Erdjument-Bromage H, Aziz Z, Robbins-Juarez SY, Chavez EY, Ahlsen G, Katsamba PS, Neubert TA, Fitzpatrick AWP, Barasch J, Shapiro L. Cell 186 821-836.e13 (2023)
Reviews citing this publication (64)
- Reelin and brain development. Tissir F, Goffinet AM. Nat Rev Neurosci 4 496-505 (2003)
- LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies. Lillis AP, Van Duyn LB, Murphy-Ullrich JE, Strickland DK. Physiol Rev 88 887-918 (2008)
- Endocytic mechanisms for targeted drug delivery. Bareford LM, Swaan PW. Adv Drug Deliv Rev 59 748-758 (2007)
- Monogenic hypercholesterolemia: new insights in pathogenesis and treatment. Rader DJ, Cohen J, Hobbs HH. J Clin Invest 111 1795-1803 (2003)
- Molecular mechanisms of steroid hormone signaling in plants. Vert G, Nemhauser JL, Geldner N, Hong F, Chory J. Annu Rev Cell Dev Biol 21 177-201 (2005)
- Structure and physiologic function of the low-density lipoprotein receptor. Jeon H, Blacklow SC. Annu Rev Biochem 74 535-562 (2005)
- Beyond endocytosis: LRP function in cell migration, proliferation and vascular permeability. Lillis AP, Mikhailenko I, Strickland DK. J Thromb Haemost 3 1884-1893 (2005)
- Lipid-Based Drug Delivery Systems in Cancer Therapy: What Is Available and What Is Yet to Come. Yingchoncharoen P, Kalinowski DS, Richardson DR. Pharmacol Rev 68 701-787 (2016)
- Insect vitellogenin/lipophorin receptors: molecular structures, role in oogenesis, and regulatory mechanisms. Tufail M, Takeda M. J Insect Physiol 55 87-103 (2009)
- The LDL receptor: how acid pulls the trigger. Beglova N, Blacklow SC. Trends Biochem Sci 30 309-317 (2005)
- The role of MuSK in synapse formation and neuromuscular disease. Burden SJ, Yumoto N, Zhang W. Cold Spring Harb Perspect Biol 5 a009167 (2013)
- Uncoating of human rhinoviruses. Fuchs R, Blaas D. Rev Med Virol 20 281-297 (2010)
- Low-density lipoprotein receptor-related protein-1: role in the regulation of vascular integrity. Strickland DK, Au DT, Cunfer P, Muratoglu SC. Arterioscler Thromb Vasc Biol 34 487-498 (2014)
- The role of the kidney in lipid metabolism. Moestrup SK, Nielsen LB. Curr Opin Lipidol 16 301-306 (2005)
- Role of endosomes and lysosomes in human disease. Maxfield FR. Cold Spring Harb Perspect Biol 6 a016931 (2014)
- The low-density lipoprotein receptor: ligands, debates and lore. Rudenko G, Deisenhofer J. Curr Opin Struct Biol 13 683-689 (2003)
- Inhibitory serpins. New insights into their folding, polymerization, regulation and clearance. Gettins PG, Olson ST. Biochem J 473 2273-2293 (2016)
- Anomalous diffraction in crystallographic phase evaluation. Hendrickson WA. Q Rev Biophys 47 49-93 (2014)
- Circulatory lipid transport: lipoprotein assembly and function from an evolutionary perspective. Van der Horst DJ, Roosendaal SD, Rodenburg KW. Mol Cell Biochem 326 105-119 (2009)
- Sorting an LDL receptor with bound PCSK9 to intracellular degradation. Leren TP. Atherosclerosis 237 76-81 (2014)
- Sweeping antibody as a novel therapeutic antibody modality capable of eliminating soluble antigens from circulation. Igawa T, Haraya K, Hattori K. Immunol Rev 270 132-151 (2016)
- PCSK9: an emerging target for treatment of hypercholesterolemia. Duff CJ, Hooper NM. Expert Opin Ther Targets 15 157-168 (2011)
- Regulation of PCSK9 by nutraceuticals. Momtazi AA, Banach M, Pirro M, Katsiki N, Sahebkar A. Pharmacol Res 120 157-169 (2017)
- Synthetic mimics of mammalian cell surface receptors: prosthetic molecules that augment living cells. Peterson BR. Org Biomol Chem 3 3607-3612 (2005)
- The stability of 2-state, 3-state and more-state proteins from simple spectroscopic techniques... plus the structure of the equilibrium intermediates at the same time. Sancho J. Arch Biochem Biophys 531 4-13 (2013)
- Synthetic cell surface receptors for delivery of therapeutics and probes. Hymel D, Peterson BR. Adv Drug Deliv Rev 64 797-810 (2012)
- Regulation of LRP-1 expression: make the point. Emonard H, Théret L, Bennasroune AH, Dedieu S. Pathol Biol (Paris) 62 84-90 (2014)
- How calcium makes endocytic receptors attractive. Andersen CB, Moestrup SK. Trends Biochem Sci 39 82-90 (2014)
- Risk factor SORL1: from genetic association to functional validation in Alzheimer's disease. Andersen OM, Rudolph IM, Willnow TE. Acta Neuropathol 132 653-665 (2016)
- The "Phagocytic Synapse" and Clearance of Apoptotic Cells. Barth ND, Marwick JA, Vendrell M, Rossi AG, Dransfield I. Front Immunol 8 1708 (2017)
- A functional transmembrane complex: the luteinizing hormone receptor with bound ligand and G protein. Puett D, Li Y, DeMars G, Angelova K, Fanelli F. Mol Cell Endocrinol 260-262 126-136 (2007)
- Primary hypercholesterolemia: genetic causes and treatment of five monogenic disorders. Pullinger CR, Kane JP, Malloy MJ. Expert Rev Cardiovasc Ther 1 107-119 (2003)
- Sorting receptor SORLA: cellular mechanisms and implications for disease. Schmidt V, Subkhangulova A, Willnow TE. Cell Mol Life Sci 74 1475-1483 (2017)
- Low Density Lipoprotein Receptor Related Proteins as Regulators of Neural Stem and Progenitor Cell Function. Auderset L, Landowski LM, Foa L, Young KM. Stem Cells Int 2016 2108495 (2016)
- PCSK9 and diabetes: is there a link? Momtazi AA, Banach M, Pirro M, Stein EA, Sahebkar A. Drug Discov Today 22 883-895 (2017)
- Pathways of protein and lipid receptor-mediated transcytosis in drug delivery. Thuenauer R, Müller SK, Römer W. Expert Opin Drug Deliv 14 341-351 (2017)
- Hypercholesterolemia, low density lipoprotein receptor and proprotein convertase subtilisin/kexin-type 9. Gu HM, Zhang DW. J Biomed Res 29 356-361 (2015)
- Targeted Drug Delivery to Hepatic Stellate Cells for the Treatment of Liver Fibrosis. Chen Z, Jain A, Liu H, Zhao Z, Cheng K. J Pharmacol Exp Ther 370 695-702 (2019)
- An intramolecular spin of the LDL receptor beta propeller. Jeon H, Blacklow SC. Structure 11 133-136 (2003)
- The life cycle of the low-density lipoprotein receptor: insights from cellular and in-vivo studies. Wijers M, Kuivenhoven JA, van de Sluis B. Curr Opin Lipidol 26 82-87 (2015)
- Endocytic receptor LRP2/megalin-of holoprosencephaly and renal Fanconi syndrome. Willnow TE, Christ A. Pflugers Arch 469 907-916 (2017)
- Molecular pathology of familial hypercholesterolemia, related dyslipidemias and therapies beyond the statins. Faiz F, Hooper AJ, van Bockxmeer FM. Crit Rev Clin Lab Sci 49 1-17 (2012)
- The switch on the RAPper's necklace... Herz J. Mol Cell 23 451-455 (2006)
- Harnessing low-density lipoprotein receptor protein 6 (LRP6) genetic variation and Wnt signaling for innovative diagnostics in complex diseases. Wang ZM, Luo JQ, Xu LY, Zhou HH, Zhang W. Pharmacogenomics J 18 351-358 (2018)
- Dissecting the Extracellular Complexity of Neuromuscular Junction Organizers. Guarino SR, Canciani A, Forneris F. Front Mol Biosci 6 156 (2019)
- Validation of LDLr Activity as a Tool to Improve Genetic Diagnosis of Familial Hypercholesterolemia: A Retrospective on Functional Characterization of LDLr Variants. Benito-Vicente A, Uribe KB, Jebari S, Galicia-Garcia U, Ostolaza H, Martin C. Int J Mol Sci 19 (2018)
- Proteostasis Regulation in the Endoplasmic Reticulum: An Emerging Theme in the Molecular Pathology and Therapeutic Management of Familial Hypercholesterolemia. Oommen D, Kizhakkedath P, Jawabri AA, Varghese DS, Ali BR. Front Genet 11 570355 (2020)
- Genetic Markers for Coronary Artery Disease. Veljkovic N, Zaric B, Djuric I, Obradovic M, Sudar-Milovanovic E, Radak D, Isenovic ER. Medicina (Kaunas) 54 (2018)
- New light on a long-known protein family. Andersen OM, Petersen HH. Chembiochem 4 1137-1146 (2003)
- Proprotein convertase subtilisin/kexin type 9: from the discovery to the development of new therapies for cardiovascular diseases. Ferri N. Scientifica (Cairo) 2012 927352 (2012)
- ApoER2: Functional Tuning Through Splicing. Gallo CM, Ho A, Beffert U. Front Mol Neurosci 13 144 (2020)
- Function of the endolysosomal network in cholesterol homeostasis and metabolic-associated fatty liver disease (MAFLD). Vos DY, van de Sluis B. Mol Metab 50 101146 (2021)
- LRPs in WNT Signalling. Davidson G. Handb Exp Pharmacol 269 45-73 (2021)
- Structural biology: a high-tech tool for biomedical research. Machius M. Curr Opin Nephrol Hypertens 12 431-438 (2003)
- Vaccines Targeting PSCK9 for the Treatment of Hyperlipidemia. Toth S, Pella D, Fedacko J. Cardiol Ther 9 323-332 (2020)
- Cholesterol and Alzheimer's Disease; From Risk Genes to Pathological Effects. Feringa FM, van der Kant R. Front Aging Neurosci 13 690372 (2021)
- Endocrine Regulation of Microvascular Receptor-Mediated Transcytosis and Its Therapeutic Opportunities: Insights by PCSK9-Mediated Regulation. Mazura AD, Pietrzik CU. Pharmaceutics 15 1268 (2023)
- Endocytic Protein Defects in the Neural Crest Cell Lineage and Its Pathway Are Associated with Congenital Heart Defects. Arrigo AB, Lin JI. Int J Mol Sci 22 (2021)
- Extracellular targeted protein degradation: an emerging modality for drug discovery. Wells JA, Kumru K. Nat Rev Drug Discov (2023)
- How multi-scale structural biology elucidated context-dependent variability in ectodomain conformation along with the ligand capture and release cycle for LDLR family members. Nogi T. Biophys Rev 10 481-492 (2018)
- LRP6 Receptor Plays Essential Functions in Development and Human Diseases. Alrefaei AF, Abu-Elmagd M. Genes (Basel) 13 120 (2022)
- Neurotrophins as Key Regulators of Cell Metabolism: Implications for Cholesterol Homeostasis. Colardo M, Martella N, Pensabene D, Siteni S, Di Bartolomeo S, Pallottini V, Segatto M. Int J Mol Sci 22 (2021)
- Potential of Phage Display Antibody Technology for Cardiovascular Disease Immunotherapy. Yeoh SG, Sum JS, Lai JY, W Isa WYH, Lim TS. J Cardiovasc Transl Res (2021)
- Role of Cholesterol and Lipid Rafts in Cancer Signaling: A Promising Therapeutic Opportunity? Vona R, Iessi E, Matarrese P. Front Cell Dev Biol 9 622908 (2021)
Articles citing this publication (188)
- Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation. Zhang DW, Lagace TA, Garuti R, Zhao Z, McDonald M, Horton JD, Cohen JC, Hobbs HH. J Biol Chem 282 18602-18612 (2007)
- Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice. Lagace TA, Curtis DE, Garuti R, McNutt MC, Park SW, Prather HB, Anderson NN, Ho YK, Hammer RE, Horton JD. J Clin Invest 116 2995-3005 (2006)
- PCSK9: a convertase that coordinates LDL catabolism. Horton JD, Cohen JC, Hobbs HH. J Lipid Res 50 Suppl S172-7 (2009)
- Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia. Cunningham D, Danley DE, Geoghegan KF, Griffor MC, Hawkins JL, Subashi TA, Varghese AH, Ammirati MJ, Culp JS, Hoth LR, Mansour MN, McGrath KM, Seddon AP, Shenolikar S, Stutzman-Engwall KJ, Warren LC, Xia D, Qiu X. Nat Struct Mol Biol 14 413-419 (2007)
- Molecular basis for LDL receptor recognition by PCSK9. Kwon HJ, Lagace TA, McNutt MC, Horton JD, Deisenhofer J. Proc Natl Acad Sci U S A 105 1820-1825 (2008)
- Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis. van Meurs JB, Trikalinos TA, Ralston SH, Balcells S, Brandi ML, Brixen K, Kiel DP, Langdahl BL, Lips P, Ljunggren O, Lorenc R, Obermayer-Pietsch B, Ohlsson C, Pettersson U, Reid DM, Rousseau F, Scollen S, Van Hul W, Agueda L, Akesson K, Benevolenskaya LI, Ferrari SL, Hallmans G, Hofman A, Husted LB, Kruk M, Kaptoge S, Karasik D, Karlsson MK, Lorentzon M, Masi L, McGuigan FE, Mellström D, Mosekilde L, Nogues X, Nogues X, Pols HA, Reeve J, Renner W, Rivadeneira F, van Schoor NM, Weber K, Ioannidis JP, Uitterlinden AG, GENOMOS Study. JAMA 299 1277-1290 (2008)
- Structural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptor. Zhang DW, Garuti R, Tang WJ, Cohen JC, Hobbs HH. Proc Natl Acad Sci U S A 105 13045-13050 (2008)
- The crystal structure of PCSK9: a regulator of plasma LDL-cholesterol. Piper DE, Jackson S, Liu Q, Romanow WG, Shetterly S, Thibault ST, Shan B, Walker NP. Structure 15 545-552 (2007)
- Structure of an LDLR-RAP complex reveals a general mode for ligand recognition by lipoprotein receptors. Fisher C, Beglova N, Blacklow SC. Mol Cell 22 277-283 (2006)
- Crystal structures of the extracellular domain of LRP6 and its complex with DKK1. Cheng Z, Biechele T, Wei Z, Morrone S, Moon RT, Wang L, Xu W. Nat Struct Mol Biol 18 1204-1210 (2011)
- Structure of the semaphorin-3A receptor binding module. Antipenko A, Himanen JP, van Leyen K, Nardi-Dei V, Lesniak J, Barton WA, Rajashankar KR, Lu M, Hoemme C, Püschel AW, Nikolov DB. Neuron 39 589-598 (2003)
- Effects of pH and low density lipoprotein (LDL) on PCSK9-dependent LDL receptor regulation. Fisher TS, Lo Surdo P, Pandit S, Mattu M, Santoro JC, Wisniewski D, Cummings RT, Calzetta A, Cubbon RM, Fischer PA, Tarachandani A, De Francesco R, Wright SD, Sparrow CP, Carfi A, Sitlani A. J Biol Chem 282 20502-20512 (2007)
- Complex between nidogen and laminin fragments reveals a paradigmatic beta-propeller interface. Takagi J, Yang Y, Liu JH, Wang JH, Springer TA. Nature 424 969-974 (2003)
- Antagonism of secreted PCSK9 increases low density lipoprotein receptor expression in HepG2 cells. McNutt MC, Kwon HJ, Chen C, Chen JR, Horton JD, Lagace TA. J Biol Chem 284 10561-10570 (2009)
- Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies. Ettenberg SA, Charlat O, Daley MP, Liu S, Vincent KJ, Stuart DD, Schuller AG, Yuan J, Ospina B, Green J, Yu Q, Walsh R, Li S, Schmitz R, Heine H, Bilic S, Ostrom L, Mosher R, Hartlepp KF, Zhu Z, Fawell S, Yao YM, Stover D, Finan PM, Porter JA, Sellers WR, Klagge IM, Cong F. Proc Natl Acad Sci U S A 107 15473-15478 (2010)
- Molecular characterization of the haptoglobin.hemoglobin receptor CD163. Ligand binding properties of the scavenger receptor cysteine-rich domain region. Madsen M, Møller HJ, Nielsen MJ, Jacobsen C, Graversen JH, Graversen JH, van den Berg T, Moestrup SK. J Biol Chem 279 51561-51567 (2004)
- Structural basis of semaphorin-plexin recognition and viral mimicry from Sema7A and A39R complexes with PlexinC1. Liu H, Juo ZS, Shim AH, Focia PJ, Chen X, Garcia KC, He X. Cell 142 749-761 (2010)
- X-ray structure of a minor group human rhinovirus bound to a fragment of its cellular receptor protein. Verdaguer N, Fita I, Reithmayer M, Moser R, Blaas D. Nat Struct Mol Biol 11 429-434 (2004)
- NetCGlyc 1.0: prediction of mammalian C-mannosylation sites. Julenius K. Glycobiology 17 868-876 (2007)
- Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6. Ahn VE, Chu ML, Choi HJ, Tran D, Abo A, Weis WI. Dev Cell 21 862-873 (2011)
- Wnt antagonists bind through a short peptide to the first β-propeller domain of LRP5/6. Bourhis E, Wang W, Tam C, Hwang J, Zhang Y, Spittler D, Huang OW, Gong Y, Estevez A, Zilberleyb I, Rouge L, Chiu C, Wu Y, Costa M, Hannoush RN, Franke Y, Cochran AG. Structure 19 1433-1442 (2011)
- Agrin binds to the N-terminal region of Lrp4 protein and stimulates association between Lrp4 and the first immunoglobulin-like domain in muscle-specific kinase (MuSK). Zhang W, Coldefy AS, Hubbard SR, Burden SJ. J Biol Chem 286 40624-40630 (2011)
- Crystal structure of human lectin-like, oxidized low-density lipoprotein receptor 1 ligand binding domain and its ligand recognition mode to OxLDL. Ohki I, Ishigaki T, Oyama T, Matsunaga S, Xie Q, Ohnishi-Kameyama M, Murata T, Tsuchiya D, Machida S, Morikawa K, Tate S. Structure 13 905-917 (2005)
- Structural and functional studies of LRP6 ectodomain reveal a platform for Wnt signaling. Chen S, Bubeck D, MacDonald BT, Liang WX, Mao JH, Malinauskas T, Llorca O, Aricescu AR, Siebold C, He X, Jones EY. Dev Cell 21 848-861 (2011)
- Multiple receptors involved in human rhinovirus attachment to live cells. Rankl C, Kienberger F, Wildling L, Wruss J, Gruber HJ, Blaas D, Hinterdorfer P. Proc Natl Acad Sci U S A 105 17778-17783 (2008)
- A common polymorphism decreases low-density lipoprotein receptor exon 12 splicing efficiency and associates with increased cholesterol. Zhu H, Tucker HM, Grear KE, Simpson JF, Manning AK, Cupples LA, Estus S. Hum Mol Genet 16 1765-1772 (2007)
- Human rhinovirus type 2 is internalized by clathrin-mediated endocytosis. Snyers L, Zwickl H, Blaas D. J Virol 77 5360-5369 (2003)
- Lumbricus erythrocruorin at 3.5 A resolution: architecture of a megadalton respiratory complex. Royer WE, Sharma H, Strand K, Knapp JE, Bhyravbhatla B. Structure 14 1167-1177 (2006)
- Two phases of disulfide bond formation have differing requirements for oxygen. Koritzinsky M, Levitin F, van den Beucken T, van den Beucken T, Rumantir RA, Harding NJ, Chu KC, Boutros PC, Braakman I, Wouters BG. J Cell Biol 203 615-627 (2013)
- Retention of mutant low density lipoprotein receptor in endoplasmic reticulum (ER) leads to ER stress. Sørensen S, Ranheim T, Bakken KS, Leren TP, Kulseth MA. J Biol Chem 281 468-476 (2006)
- A pH-regulated dimeric bouquet in the structure of von Willebrand factor. Zhou YF, Eng ET, Nishida N, Lu C, Walz T, Springer TA. EMBO J 30 4098-4111 (2011)
- Novel LRP5 missense mutation in a patient with a high bone mass phenotype results in decreased DKK1-mediated inhibition of Wnt signaling. Balemans W, Devogelaer JP, Cleiren E, Piters E, Caussin E, Van Hul W. J Bone Miner Res 22 708-716 (2007)
- A two-step binding model of PCSK9 interaction with the low density lipoprotein receptor. Yamamoto T, Lu C, Ryan RO. J Biol Chem 286 5464-5470 (2011)
- Differential endocytic sorting of p75NTR and TrkA in response to NGF: a role for late endosomes in TrkA trafficking. Saxena S, Howe CL, Cosgaya JM, Steiner P, Hirling H, Chan JR, Weis J, Krüttgen A. Mol Cell Neurosci 28 571-587 (2005)
- Morphology and structure of lipoproteins revealed by an optimized negative-staining protocol of electron microscopy. Zhang L, Song J, Cavigiolio G, Ishida BY, Zhang S, Kane JP, Weisgraber KH, Oda MN, Rye KA, Pownall HJ, Ren G. J Lipid Res 52 175-184 (2011)
- Mouse matriptase-2: identification, characterization and comparative mRNA expression analysis with mouse hepsin in adult and embryonic tissues. Hooper JD, Campagnolo L, Goodarzi G, Truong TN, Stuhlmann H, Quigley JP. Biochem J 373 689-702 (2003)
- Cooperation between fixed and low pH-inducible interfaces controls lipoprotein release by the LDL receptor. Beglova N, Jeon H, Fisher C, Blacklow SC. Mol Cell 16 281-292 (2004)
- Molecular characterization of proprotein convertase subtilisin/kexin type 9-mediated degradation of the LDLR. Wang Y, Huang Y, Hobbs HH, Cohen JC. J Lipid Res 53 1932-1943 (2012)
- Structure of a receptor-binding fragment of reelin and mutational analysis reveal a recognition mechanism similar to endocytic receptors. Yasui N, Nogi T, Kitao T, Nakano Y, Hattori M, Takagi J. Proc Natl Acad Sci U S A 104 9988-9993 (2007)
- Binding site structure of one LRP-RAP complex: implications for a common ligand-receptor binding motif. Jensen GA, Andersen OM, Bonvin AM, Bjerrum-Bohr I, Etzerodt M, Thøgersen HC, O'Shea C, Poulsen FM, Kragelund BB. J Mol Biol 362 700-716 (2006)
- Structural basis for specific recognition of reelin by its receptors. Yasui N, Nogi T, Takagi J. Structure 18 320-331 (2010)
- The modular adaptor protein ARH is required for low density lipoprotein (LDL) binding and internalization but not for LDL receptor clustering in coated pits. Michaely P, Li WP, Anderson RG, Cohen JC, Hobbs HH. J Biol Chem 279 34023-34031 (2004)
- Coaxing the LDL receptor family into the fold. Herz J, Marschang P. Cell 112 289-292 (2003)
- Structural insight into the mechanisms of Wnt signaling antagonism by Dkk. Chen L, Wang K, Shao Y, Huang J, Li X, Shan J, Wu D, Zheng JJ. J Biol Chem 283 23364-23370 (2008)
- Sensor domain of the Mycobacterium tuberculosis receptor Ser/Thr protein kinase, PknD, forms a highly symmetric beta propeller. Good MC, Greenstein AE, Young TA, Ng HL, Alber T. J Mol Biol 339 459-469 (2004)
- Advances in genetics show the need for extending screening strategies for autosomal dominant hypercholesterolaemia. Motazacker MM, Pirruccello J, Huijgen R, Do R, Gabriel S, Peter J, Kuivenhoven JA, Defesche JC, Kastelein JJ, Hovingh GK, Zelcer N, Kathiresan S, Fouchier SW. Eur Heart J 33 1360-1366 (2012)
- Structure of uPAR, plasminogen, and sugar-binding sites of the 300 kDa mannose 6-phosphate receptor. Olson LJ, Yammani RD, Dahms NM, Kim JJ. EMBO J 23 2019-2028 (2004)
- Blood protein coating of gold nanoparticles as potential tool for organ targeting. Schäffler M, Sousa F, Wenk A, Sitia L, Hirn S, Schleh C, Haberl N, Violatto M, Canovi M, Andreozzi P, Salmona M, Bigini P, Kreyling WG, Krol S. Biomaterials 35 3455-3466 (2014)
- Interaction between the ligand-binding domain of the LDL receptor and the C-terminal domain of PCSK9 is required for PCSK9 to remain bound to the LDL receptor during endosomal acidification. Tveten K, Holla ØL, Cameron J, Strøm TB, Berge KE, Laerdahl JK, Leren TP. Hum Mol Genet 21 1402-1409 (2012)
- Structure of the minimal interface between ApoE and LRP. Guttman M, Prieto JH, Handel TM, Domaille PJ, Komives EA. J Mol Biol 398 306-319 (2010)
- PCSK9 function and physiology. Peterson AS, Fong LG, Young SG. J Lipid Res 49 1595-1599 (2008)
- NPC1L1 (Niemann-Pick C1-like 1) mediates sterol-specific unidirectional transport of non-esterified cholesterol in McArdle-RH7777 hepatoma cells. Brown JM, Rudel LL, Yu L. Biochem J 406 273-283 (2007)
- Vitellogenin receptor mutation leads to the oogenesis mutant phenotype "scanty vitellin" of the silkworm, Bombyx mori. Lin Y, Meng Y, Wang YX, Luo J, Katsuma S, Yang CW, Banno Y, Kusakabe T, Shimada T, Xia QY. J Biol Chem 288 13345-13355 (2013)
- Mechanism of low density lipoprotein (LDL) release in the endosome: implications of the stability and Ca2+ affinity of the fifth binding module of the LDL receptor. Arias-Moreno X, Velazquez-Campoy A, Rodríguez JC, Pocoví M, Sancho J. J Biol Chem 283 22670-22679 (2008)
- Role of the C-terminal domain of PCSK9 in degradation of the LDL receptors. Holla ØL, Cameron J, Tveten K, Strøm TB, Berge KE, Laerdahl JK, Leren TP. J Lipid Res 52 1787-1794 (2011)
- Structural basis for the recognition of LDL-receptor family members by VSV glycoprotein. Nikolic J, Belot L, Raux H, Legrand P, Gaudin Y, A Albertini A. Nat Commun 9 1029 (2018)
- Boca-dependent maturation of beta-propeller/EGF modules in low-density lipoprotein receptor proteins. Culi J, Springer TA, Mann RS. EMBO J 23 1372-1380 (2004)
- A unified scheme for initiation and conformational adaptation of human apolipoprotein E N-terminal domain upon lipoprotein binding and for receptor binding activity. Sivashanmugam A, Wang J. J Biol Chem 284 14657-14666 (2009)
- Mutation in EGFP domain of LDL receptor-related protein 6 impairs cellular LDL clearance. Liu W, Mani S, Davis NR, Sarrafzadegan N, Kavathas PB, Mani A. Circ Res 103 1280-1288 (2008)
- Cholesterol substrate pools and steroid hormone levels are normal in the face of mutational inactivation of NPC1 protein. Xie C, Richardson JA, Turley SD, Dietschy JM. J Lipid Res 47 953-963 (2006)
- Receptor-mediated and bulk-phase endocytosis cause macrophage and cholesterol accumulation in Niemann-Pick C disease. Liu B, Xie C, Richardson JA, Turley SD, Dietschy JM. J Lipid Res 48 1710-1723 (2007)
- Apolipoprotein E isoform-specific binding to the low-density lipoprotein receptor. Yamamoto T, Choi HW, Ryan RO. Anal Biochem 372 222-226 (2008)
- Structure-based mutation analysis shows the importance of LRP5 beta-propeller 1 in modulating Dkk1-mediated inhibition of Wnt signaling. Bhat BM, Allen KM, Liu W, Graham J, Morales A, Anisowicz A, Lam HS, McCauley C, Coleburn V, Cain M, Fortier E, Bhat RA, Bex FJ, Yaworsky PJ. Gene 391 103-112 (2007)
- A family with osteoporosis pseudoglioma syndrome due to compound heterozygosity of two novel mutations in the LRP5 gene. Cheung WM, Jin LY, Smith DK, Cheung PT, Kwan EY, Low L, Kung AW. Bone 39 470-476 (2006)
- Hen egg-white lysozyme crystallisation: protein stacking and structure stability enhanced by a Tellurium(VI)-centred polyoxotungstate. Bijelic A, Molitor C, Mauracher SG, Al-Oweini R, Kortz U, Rompel A. Chembiochem 16 233-241 (2015)
- Solution structures of the first and fourth TSR domains of F-spondin. Pääkkönen K, Tossavainen H, Permi P, Rakkolainen H, Rauvala H, Raulo E, Kilpeläinen I, Güntert P. Proteins 64 665-672 (2006)
- Structural characterization of carbohydrate binding by LMAN1 protein provides new insight into the endoplasmic reticulum export of factors V (FV) and VIII (FVIII). Zheng C, Page RC, Das V, Nix JC, Wigren E, Misra S, Zhang B. J Biol Chem 288 20499-20509 (2013)
- New hypotheses about the structure-function of proprotein convertase subtilisin/kexin type 9: analysis of the epidermal growth factor-like repeat A docking site using WaterMap. Pearlstein RA, Hu QY, Zhou J, Yowe D, Levell J, Dale B, Kaushik VK, Daniels D, Hanrahan S, Sherman W, Abel R. Proteins 78 2571-2586 (2010)
- Sequence and structure of human rhinoviruses reveal the basis of receptor discrimination. Vlasak M, Blomqvist S, Hovi T, Hewat E, Blaas D. J Virol 77 6923-6930 (2003)
- Low density lipoprotein receptor class A repeats are O-glycosylated in linker regions. Pedersen NB, Wang S, Narimatsu Y, Yang Z, Halim A, Schjoldager KT, Madsen TD, Seidah NG, Bennett EP, Levery SB, Clausen H. J Biol Chem 289 17312-17324 (2014)
- PCSK9 function and physiology. Peterson AS, Fong LG, Young SG. J Lipid Res 49 1152-1156 (2008)
- Productive entry pathways of human rhinoviruses. Fuchs R, Blaas D. Adv Virol 2012 826301 (2012)
- Receptor-associated protein (RAP) has two high-affinity binding sites for the low-density lipoprotein receptor-related protein (LRP): consequences for the chaperone functions of RAP. Jensen JK, Dolmer K, Schar C, Gettins PG. Biochem J 421 273-282 (2009)
- An inquiry into protein structure and genetic disease: introducing undergraduates to bioinformatics in a large introductory course. Bednarski AE, Elgin SC, Pakrasi HB. Cell Biol Educ 4 207-220 (2005)
- Site-specific O-glycosylation of members of the low-density lipoprotein receptor superfamily enhances ligand interactions. Wang S, Mao Y, Narimatsu Y, Ye Z, Tian W, Goth CK, Lira-Navarrete E, Pedersen NB, Benito-Vicente A, Martin C, Uribe KB, Hurtado-Guerrero R, Christoffersen C, Seidah NG, Nielsen R, Christensen EI, Hansen L, Bennett EP, Vakhrushev SY, Schjoldager KT, Clausen H. J Biol Chem 293 7408-7422 (2018)
- Functional characterization and classification of frequent low-density lipoprotein receptor variants. Etxebarria A, Benito-Vicente A, Palacios L, Stef M, Cenarro A, Civeira F, Ostolaza H, Martin C. Hum Mutat 36 129-141 (2015)
- The epidermal growth factor homology domain of the LDL receptor drives lipoprotein release through an allosteric mechanism involving H190, H562, and H586. Zhao Z, Michaely P. J Biol Chem 283 26528-26537 (2008)
- Adaptor protein ARH is recruited to the plasma membrane by low density lipoprotein (LDL) binding and modulates endocytosis of the LDL/LDL receptor complex in hepatocytes. Sirinian MI, Belleudi F, Campagna F, Ceridono M, Garofalo T, Quagliarini F, Verna R, Calandra S, Bertolini S, Sorice M, Torrisi MR, Arca M. J Biol Chem 280 38416-38423 (2005)
- LRAD3, a novel low-density lipoprotein receptor family member that modulates amyloid precursor protein trafficking. Ranganathan S, Noyes NC, Migliorini M, Winkles JA, Battey FD, Hyman BT, Smith E, Yepes M, Mikhailenko I, Strickland DK. J Neurosci 31 10836-10846 (2011)
- PCSK9-mediated degradation of the LDL receptor generates a 17 kDa C-terminal LDL receptor fragment. Tveten K, Str M TB, Berge KE, Leren TP. J Lipid Res 54 1560-1566 (2013)
- The linkage between ribosomal crystallography, metal ions, heteropolytungstates and functional flexibility. Bashan A, Yonath A. J Mol Struct 890 289-294 (2008)
- Calcium as a crucial cofactor for low density lipoprotein receptor folding in the endoplasmic reticulum. Pena F, Jansens A, van Zadelhoff G, Braakman I. J Biol Chem 285 8656-8664 (2010)
- Neutralization of a common cold virus by concatemers of the third ligand binding module of the VLDL-receptor strongly depends on the number of modules. Moser R, Snyers L, Wruss J, Angulo J, Peters H, Peters T, Blaas D. Virology 338 259-269 (2005)
- The role of calcium in lipoprotein release by the low-density lipoprotein receptor. Zhao Z, Michaely P. Biochemistry 48 7313-7324 (2009)
- An antibody against the C-terminal domain of PCSK9 lowers LDL cholesterol levels in vivo. Schiele F, Park J, Redemann N, Luippold G, Nar H. J Mol Biol 426 843-852 (2014)
- Extracellular matrices of the avian ovarian follicle. Molecular characterization of chicken perlecan. Hummel S, Osanger A, Bajari TM, Balasubramani M, Halfter W, Nimpf J, Schneider WJ. J Biol Chem 279 23486-23494 (2004)
- K Domain CR9 of Low Density Lipoprotein (LDL) Receptor-related Protein 1 (LRP1) Is Critical for Aggregated LDL-induced Foam Cell Formation from Human Vascular Smooth Muscle Cells. Costales P, Fuentes-Prior P, Castellano J, Revuelta-Lopez E, Corral-Rodríguez MÁ, Nasarre L, Badimon L, Llorente-Cortes V. J Biol Chem 290 14852-14865 (2015)
- Molecular studies of pH-dependent ligand interactions with the low-density lipoprotein receptor. Yamamoto T, Chen HC, Guigard E, Kay CM, Ryan RO. Biochemistry 47 11647-11652 (2008)
- The COP II adaptor protein TMED7 is required to initiate and mediate the delivery of TLR4 to the plasma membrane. Liaunardy-Jopeace A, Bryant CE, Gay NJ. Sci Signal 7 ra70 (2014)
- Binding areas of urokinase-type plasminogen activator-plasminogen activator inhibitor-1 complex for endocytosis receptors of the low-density lipoprotein receptor family, determined by site-directed mutagenesis. Skeldal S, Larsen JV, Pedersen KE, Petersen HH, Egelund R, Christensen A, Jensen JK, Gliemann J, Andreasen PA. FEBS J 273 5143-5159 (2006)
- Effect of curcumin on the expression of LDL receptor in mouse macrophages. Fan C, Wo X, Qian Y, Yin J, Gao L. J Ethnopharmacol 105 251-254 (2006)
- Structure of the tau60/Delta tau91 subcomplex of yeast transcription factor IIIC: insights into preinitiation complex assembly. Mylona A, Fernández-Tornero C, Legrand P, Haupt M, Sentenac A, Acker J, Müller CW. Mol Cell 24 221-232 (2006)
- LDL receptor/lipoprotein recognition: endosomal weakening of ApoB and ApoE binding to the convex face of the LR5 repeat. Martínez-Oliván J, Arias-Moreno X, Velazquez-Campoy A, Millet O, Sancho J. FEBS J 281 1534-1546 (2014)
- Receptor-induced conformational changes in the SU subunit of the avian sarcoma/leukosis virus A envelope protein: implications for fusion activation. Delos SE, Godby JA, White JM. J Virol 79 3488-3499 (2005)
- The structure of receptor-associated protein (RAP). Lee D, Lee D, Walsh JD, Migliorini M, Yu P, Cai T, Schwieters CD, Krueger S, Strickland DK, Wang YX. Protein Sci 16 1628-1640 (2007)
- The structure, dynamics, and binding of the LA45 module pair of the low-density lipoprotein receptor suggest an important role for LA4 in ligand release. Guttman M, Komives EA. Biochemistry 50 11001-11008 (2011)
- A single lysine of the two-lysine recognition motif of the D3 domain of receptor-associated protein is sufficient to mediate endocytosis by low-density lipoprotein receptor-related protein. van den Biggelaar M, Sellink E, Klein Gebbinck JW, Mertens K, Meijer AB. Int J Biochem Cell Biol 43 431-440 (2011)
- Atomic structure of the autosomal recessive hypercholesterolemia phosphotyrosine-binding domain in complex with the LDL-receptor tail. Dvir H, Shah M, Girardi E, Guo L, Farquhar MG, Zajonc DM. Proc Natl Acad Sci U S A 109 6916-6921 (2012)
- Characterization of the role of EGF-A of low density lipoprotein receptor in PCSK9 binding. Gu HM, Adijiang A, Mah M, Zhang DW. J Lipid Res 54 3345-3357 (2013)
- Low pH-triggered beta-propeller switch of the low-density lipoprotein receptor assists rhinovirus infection. Konecsni T, Berka U, Pickl-Herk A, Bilek G, Khan AG, Gajdzig L, Fuchs R, Blaas D. J Virol 83 10922-10930 (2009)
- Specificity of binding of the low density lipoprotein receptor-related protein to different conformational states of the clade E serpins plasminogen activator inhibitor-1 and proteinase nexin-1. Jensen JK, Dolmer K, Gettins PG. J Biol Chem 284 17989-17997 (2009)
- The discrete and combined effect of SREBP-2 and SCAP isoforms in the control of plasma lipids among familial hypercholesterolaemia patients. Durst R, Jansen A, Erez G, Bravdo R, Butbul E, Ben Avi L, Shpitzen S, Lotan C, Leitersdorf E, Defesche J, Friedlander Y, Meiner V, Miserez AR. Atherosclerosis 189 443-450 (2006)
- The glycosylation-dependent interaction of perlecan core protein with LDL: implications for atherosclerosis. Xu YX, Ashline D, Liu L, Tassa C, Shaw SY, Ravid K, Layne MD, Reinhold V, Robbins PW. J Lipid Res 56 266-276 (2015)
- Three complement-like repeats compose the complete alpha2-macroglobulin binding site in the second ligand binding cluster of the low density lipoprotein receptor-related protein. Dolmer K, Gettins PG. J Biol Chem 281 34189-34196 (2006)
- Binding characteristics of a panel of monoclonal antibodies against the ligand binding domain of the human LDLr. Nguyen AT, Hirama T, Chauhan V, Mackenzie R, Milne R. J Lipid Res 47 1399-1405 (2006)
- Internalized PCSK9 dissociates from recycling LDL receptors in PCSK9-resistant SV-589 fibroblasts. Nguyen MA, Kosenko T, Lagace TA. J Lipid Res 55 266-275 (2014)
- The first propeller domain of LRP6 regulates sensitivity to DKK1. Binnerts ME, Tomasevic N, Bright JM, Leung J, Ahn VE, Kim KA, Zhan X, Liu S, Yonkovich S, Williams J, Zhou M, Gros D, Dixon M, Korver W, Weis WI, Abo A. Mol Biol Cell 20 3552-3560 (2009)
- Apolipoprotein E-low density lipoprotein receptor binding: study of protein-protein interaction in rationally selected docked complexes. Prévost M, Raussens V. Proteins 55 874-884 (2004)
- Human rhinovirus type 2-antibody complexes enter and infect cells via Fc-gamma receptor IIB1. Baravalle G, Brabec M, Snyers L, Blaas D, Fuchs R. J Virol 78 2729-2737 (2004)
- Mechanisms for the control of matriptase activity in the absence of sufficient HAI-1. Xu H, Xu Z, Tseng IC, Chou FP, Chen YW, Wang JK, Johnson MD, Kataoka H, Lin CY. Am J Physiol Cell Physiol 302 C453-62 (2012)
- Novel TMPRSS3 variants in Pakistani families with autosomal recessive non-syndromic hearing impairment. Lee K, Khan S, Islam A, Ansar M, Andrade PB, Kim S, Santos-Cortez RL, Ahmad W, Leal SM. Clin Genet 82 56-63 (2012)
- Predicting protein homocysteinylation targets based on dihedral strain energy and pKa of cysteines. Sundaramoorthy E, Maiti S, Brahmachari SK, Sengupta S. Proteins 71 1475-1483 (2008)
- Thermodynamics of protein-cation interaction: Ca(+2) and Mg(+2) binding to the fifth binding module of the LDL receptor. Arias-Moreno X, Cuesta-Lopez S, Millet O, Sancho J, Velazquez-Campoy A. Proteins 78 950-961 (2010)
- A proximal pair of positive charges provides the dominant ligand-binding contribution to complement-like domains from the LRP (low-density lipoprotein receptor-related protein). Gettins PG, Dolmer K. Biochem J 443 65-73 (2012)
- Activity-associated effect of LDL receptor missense variants located in the cysteine-rich repeats. Etxebarria A, Benito-Vicente A, Stef M, Ostolaza H, Palacios L, Martin C. Atherosclerosis 238 304-312 (2015)
- Characterization of low density lipoprotein receptor ligand interactions by fluorescence resonance energy transfer. Yamamoto T, Lamoureux J, Ryan RO. J Lipid Res 47 1091-1096 (2006)
- Computational diagnosis of protein conformational diseases: short molecular dynamics simulations reveal a fast unfolding of r-LDL mutants that cause familial hypercholesterolemia. Cuesta-López S, Falo F, Sancho J. Proteins 66 87-95 (2007)
- Modeling the Trypanosoma cruzi Tc85-11 protein and mapping the laminin-binding site. Marroquin-Quelopana M, Oyama S, Aguiar Pertinhez T, Spisni A, Aparecida Juliano M, Juliano L, Colli W, Alves MJ. Biochem Biophys Res Commun 325 612-618 (2004)
- Evaluation of the pharmacokinetics of all-trans-retinoic acid (ATRA) in Wistar rats after intravenous administration of ATRA loaded into tributyrin submicron emulsion and its cellular activity on caco-2 and HepG2 cell lines. Su J, Zhang N, Ho PC. J Pharm Sci 97 2844-2853 (2008)
- Low pH-induced conformational change and dimerization of sortilin triggers endocytosed ligand release. Leloup N, Lössl P, Meijer DH, Brennich M, Heck AJR, Thies-Weesie DME, Janssen BJC. Nat Commun 8 1708 (2017)
- High Affinity Binding of the Receptor-associated Protein D1D2 Domains with the Low Density Lipoprotein Receptor-related Protein (LRP1) Involves Bivalent Complex Formation: CRITICAL ROLES OF LYSINES 60 AND 191. Prasad JM, Young PA, Strickland DK. J Biol Chem 291 18430-18439 (2016)
- Identification of receptor-interacting regions of vitellogenin within evolutionarily conserved β-sheet structures by using a peptide array. Roth Z, Weil S, Aflalo ED, Manor R, Sagi A, Khalaila I. Chembiochem 14 1116-1122 (2013)
- Identification of the human rhinovirus serotype 1A binding site on the murine low-density lipoprotein receptor by using human-mouse receptor chimeras. Herdy B, Snyers L, Reithmayer M, Hinterdorfer P, Blaas D. J Virol 78 6766-6774 (2004)
- Lipidated apolipoprotein E4 structure and its receptor binding mechanism determined by a combined cross-linking coupled to mass spectrometry and molecular dynamics approach. Henry N, Krammer EM, Stengel F, Adams Q, Van Liefferinge F, Hubin E, Chaves R, Efremov R, Aebersold R, Vandenbussche G, Prévost M, Raussens V, Deroo S. PLoS Comput Biol 14 e1006165 (2018)
- Recombinant Expression of the Full-length Ectodomain of LDL Receptor-related Protein 1 (LRP1) Unravels pH-dependent Conformational Changes and the Stoichiometry of Binding with Receptor-associated Protein (RAP). De Nardis C, Lössl P, van den Biggelaar M, Madoori PK, Leloup N, Mertens K, Heck AJ, Gros P. J Biol Chem 292 912-924 (2017)
- The complex of the insect LDL receptor homolog, lipophorin receptor, LpR, and its lipoprotein ligand does not dissociate under endosomal conditions. Roosendaal SD, Kerver J, Schipper M, Rodenburg KW, Van der Horst DJ. FEBS J 275 1751-1766 (2008)
- A single point mutation in the low-density lipoprotein receptor switches the degradation of its mature protein from the proteasome to the lysosome. Martín de Llano JJ, Fuertes G, Andreu EJ, Puig O, Chaves FJ, Soutar AK, Armengod ME, Knecht E. Int J Biochem Cell Biol 38 1340-1351 (2006)
- Domain swapping reveals that low density lipoprotein (LDL) type A repeat order affects ligand binding to the LDL receptor. Yamamoto T, Ryan RO. J Biol Chem 284 13396-13400 (2009)
- Evidence That Factor VIII Forms a Bivalent Complex with the Low Density Lipoprotein (LDL) Receptor-related Protein 1 (LRP1): IDENTIFICATION OF CLUSTER IV ON LRP1 AS THE MAJOR BINDING SITE. Young PA, Migliorini M, Strickland DK. J Biol Chem 291 26035-26044 (2016)
- Functional characterization of two low-density lipoprotein receptor gene mutations in two Chinese patients with familial hypercholesterolemia. Wang H, Xu S, Sun L, Pan X, Yang S, Wang L. PLoS One 9 e92703 (2014)
- Structural basis of transcobalamin recognition by human CD320 receptor. Alam A, Woo JS, Schmitz J, Prinz B, Root K, Chen F, Bloch JS, Zenobi R, Locher KP. Nat Commun 7 12100 (2016)
- The High Affinity Binding Site on Plasminogen Activator Inhibitor-1 (PAI-1) for the Low Density Lipoprotein Receptor-related Protein (LRP1) Is Composed of Four Basic Residues. Gettins PG, Dolmer K. J Biol Chem 291 800-812 (2016)
- Challenges of diagnostic exome sequencing in an inbred founder population. Azmanov DN, Chamova T, Tankard R, Gelev V, Bynevelt M, Florez L, Tzoneva D, Zlatareva D, Guergueltcheva V, Bahlo M, Tournev I, Kalaydjieva L. Mol Genet Genomic Med 1 71-76 (2013)
- Characterization of a naturally occurring degradation product of the LDL receptor. Tveten K, Strøm TB, Cameron J, Holla ØL, Berge KE, Leren TP. Mol Genet Metab 105 149-154 (2012)
- Dissection of RAP-LRP interactions: binding of RAP and RAP fragments to complement-like repeats 7 and 8 from ligand binding cluster II of LRP. Lazic A, Dolmer K, Strickland DK, Gettins PG. Arch Biochem Biophys 450 167-175 (2006)
- LRP5 polymorphisms and response to alendronate treatment in Chinese postmenopausal women with osteoporosis. Zhou PR, Liu HJ, Liao EY, Zhang ZL, Chen DC, Liu J, Wu W, Xing XP, Xia WB, Xu L, Li M. Pharmacogenomics 15 821-831 (2014)
- Low-density lipoprotein receptor gene mutation analysis and structure-function correlation in an Omani arab family with familial hypercholesterolemia. Al-Rasadi K, Al-Waili K, Al-Zidi WA, Al-Abri AR, Al-Hinai AT, Al-Sabti HA, Al-Tobi S, Al-Zakwani I, Al-Zadjali F, Al-Hashmi K, Banerjee Y. Angiology 65 911-918 (2014)
- Polymorphism of LRP5, but not of TNFRSF11B, is associated with a decrease in bone mineral density in postmenopausal Maya-Mestizo women. Canto-Cetina T, Polanco Reyes L, González Herrera L, Rojano-Mejía D, Coral-Vázquez RM, Coronel A, Canto P. Am J Hum Biol 25 713-718 (2013)
- Structural insights into recognition of beta2-glycoprotein I by the lipoprotein receptors. Beglov D, Lee CJ, De Biasio A, Kozakov D, Brenke R, Vajda S, Beglova N. Proteins 77 940-949 (2009)
- Anionic phospholipids inhibit apolipoprotein E--low-density lipoprotein receptor interactions. Yamamoto T, Ryan RO. Biochem Biophys Res Commun 354 820-824 (2007)
- Gene structure and molecular phylogeny of the linker chains from the giant annelid hexagonal bilayer hemoglobins. Chabasse C, Bailly X, Sanchez S, Rousselot M, Zal F. J Mol Evol 63 365-374 (2006)
- Insights into Collagen Uptake by C-type Mannose Receptors from the Crystal Structure of Endo180 Domains 1-4. Paracuellos P, Briggs DC, Carafoli F, Lončar T, Hohenester E. Structure 23 2133-2142 (2015)
- Interaction of coagulation factor VIII with members of the low-density lipoprotein receptor family follows common mechanism and involves consensus residues within the A2 binding site 484-509. Ananyeva NM, Makogonenko YM, Sarafanov AG, Pechik IV, Gorlatova N, Radtke KP, Shima M, Saenko EL. Blood Coagul Fibrinolysis 19 543-555 (2008)
- LDL transcytosis by protein membrane diffusion. Kuzmenko ES, Djafarzadeh S, Cakar ZP, Fiedler K. Int J Biochem Cell Biol 36 519-534 (2004)
- Low-density lipoprotein receptor is a calcium/magnesium sensor - role of LR4 and LR5 ion interaction kinetics in low-density lipoprotein release in the endosome. Martínez-Oliván J, Rozado-Aguirre Z, Arias-Moreno X, Angarica VE, Velázquez-Campoy A, Sancho J. FEBS J 281 2638-2658 (2014)
- Development of prolactin receptor antagonists with reduced pH-dependence of receptor binding. Hansen MJ, Olsen JG, Bernichtein S, O'Shea C, Sigurskjold BW, Goffin V, Kragelund BB. J Mol Recognit 24 533-547 (2011)
- Quantitative fluorescence imaging reveals point of release for lipoproteins during LDLR-dependent uptake. Pompey S, Zhao Z, Luby-Phelps K, Michaely P. J Lipid Res 54 744-753 (2013)
- The cytoplasmic domain is not involved in directing Class 5 mutant LDL receptors to lysosomal degradation. Strøm TB, Tveten K, Holla ØL, Cameron J, Berge KE, Leren TP. Biochem Biophys Res Commun 408 642-646 (2011)
- A de novo transcriptome assembly approach elucidates the dynamics of ovarian maturation in the swordfish (Xiphias gladius). Gioacchini G, Marisaldi L, Basili D, Candelma M, Pignalosa P, Aiese Cigliano R, Sanseverino W, Hardiman G, Carnevali O. Sci Rep 9 7375 (2019)
- A mutation in the first ligand-binding repeat of the human very-low-density lipoprotein receptor results in high-affinity binding of the single V1 module to human rhinovirus 2. Nizet S, Wruss J, Landstetter N, Snyers L, Blaas D. J Virol 79 14730-14736 (2005)
- APP, APLP2 and LRP1 interact with PCSK9 but are not required for PCSK9-mediated degradation of the LDLR in vivo. Fu T, Guan Y, Xu J, Wang Y. Biochim Biophys Acta Mol Cell Biol Lipids 1862 883-889 (2017)
- Ca2+ binding to complement-type repeat domains 5 and 6 from the low-density lipoprotein receptor-related protein. Andersen OM, Vorum H, Honoré B, Thøgersen HC. BMC Biochem 4 7 (2003)
- Identification of amino acid residues in the ligand binding repeats of LDL receptor important for PCSK9 binding. Deng SJ, Alabi A, Gu HM, Adijiang A, Qin S, Zhang DW. J Lipid Res 60 516-527 (2019)
- Semisynthesis and segmental isotope labeling of the apoE3 N-terminal domain using expressed protein ligation. Hauser PS, Raussens V, Yamamoto T, Abdullahi GE, Weers PM, Sykes BD, Ryan RO. J Lipid Res 50 1548-1555 (2009)
- Studies of the autoinhibitory segment comprising residues 31-60 of the prodomain of PCSK9: Possible implications for the mechanism underlying gain-of-function mutations. Wierød L, Cameron J, Strøm TB, Leren TP. Mol Genet Metab Rep 9 86-93 (2016)
- The effect of bafilomycin A1 and protease inhibitors on the degradation and recycling of a Class 5-mutant LDLR. Tveten K, Ranheim T, Berge KE, Leren TP, Kulseth MA. Acta Biochim Biophys Sin (Shanghai) 41 246-255 (2009)
- Comment Catching the common cold. Blacklow SC. Nat Struct Mol Biol 11 388-390 (2004)
- Four cDNAs encoding lipoprotein receptors from shrimp (Pandalopsis japonica): structural characterization and expression analysis during maturation. Lee JH, Kim BK, Seo YI, Choi JH, Kang SW, Kang CK, Park WG, Kim HW. Comp Biochem Physiol B Biochem Mol Biol 169 51-62 (2014)
- Lipoprotein assembly and function in an evolutionary perspective. Van der Horst DJ, Rodenburg KW. Biomol Concepts 1 165-183 (2010)
- Structural changes induced by acidic pH in human apolipoprotein B-100. Fernández-Higuero JA, Benito-Vicente A, Etxebarria A, Milicua JC, Ostolaza H, Arrondo JL, Martín C. Sci Rep 6 36324 (2016)
- The closed conformation of the LDL receptor is destabilized by the low Ca(++) concentration but favored by the high Mg(++) concentration in the endosome. Martínez-Oliván J, Arias-Moreno X, Hurtado-Guerrero R, Carrodeguas JA, Miguel-Romero L, Marina A, Bruscolini P, Sancho J. FEBS Lett 589 3534-3540 (2015)
- The spacing between cysteines two and three of the LDL-A module of Tva is important for subgroup A avian sarcoma and leukosis virus entry. Rai T, Marble D, Rihani K, Rong L. J Virol 78 683-691 (2004)
- Intradomain Confinement of Disulfides in the Folding of Two Consecutive Modules of the LDL Receptor. Martínez-Oliván J, Fraga H, Arias-Moreno X, Ventura S, Sancho J. PLoS One 10 e0132141 (2015)
- LRP5 sequence and polymorphisms in the baboon. Doubleday AF, Kaestle FA, Cox LA, Birnbaum S, Mahaney MC, Havill LM. J Med Primatol 38 97-106 (2009)
- Marked structural rearrangement of mannose 6-phosphate/IGF2 receptor at different pH environments. Wang R, Qi X, Schmiege P, Coutavas E, Li X. Sci Adv 6 eaaz1466 (2020)
- A transient amphipathic helix in the prodomain of PCSK9 facilitates binding to low-density lipoprotein particles. Sarkar SK, Foo ACY, Matyas A, Asikhia I, Kosenko T, Goto NK, Vergara-Jaque A, Lagace TA. J Biol Chem 295 2285-2298 (2020)
- Human APOER2 Isoforms Have Differential Cleavage Events and Synaptic Properties. Omuro KC, Gallo CM, Scrandis L, Ho A, Beffert U. J Neurosci 42 4054-4068 (2022)
- Independent Severe Cases of Heterozygous Familial Hypercholesterolemia Caused by the W483X and Novel W483G Mutations in the Low-Density Lipoprotein Receptor Gene That Were Clinically Diagnosed as Homozygous Cases. Cheng S, Wu Y, Wen W, An M, Gao Y, Wang L, Han X, Shang H. Genet Test Mol Biomarkers 23 401-408 (2019)
- Knowing when to let go: endosomal release of LDL from the LDL-Receptor. Debose-Boyd RA. Mol Cell 16 160-162 (2004)
- Polymorphism of the low-density lipoprotein receptor-related protein 5 gene and fracture risk. Wang C, Zhang G, Gu M, Zhou Z, Cao X. Int J Clin Exp Med 7 5097-5103 (2014)
- Comment Predicting mortality in patients with acute lung injury. Budinger GR, Walley KR. Am J Respir Crit Care Med 184 394-395 (2011)
- Proteolysis of the low density lipoprotein receptor by bone morphogenetic protein-1 regulates cellular cholesterol uptake. Banerjee S, Andrew RJ, Duff CJ, Fisher K, Jackson CD, Lawrence CB, Maeda N, Greenspan DS, Kellett KAB, Hooper NM. Sci Rep 9 11416 (2019)
- A complete NMR spectral assignment of the conserved region of the MESD protein, MESD(12-155). Chen J, Bu G, Wang J. Biomol NMR Assign 1 3-5 (2007)
- Effects of gonadotropins, 11-ketotestosterone, and insulin-like growth factor-1 on target gene expression and growth of previtellogenic oocytes from shortfinned eels, Anguilla australis, in vitro. Nguyen AT, Damsteegt EL, Chia JHZ, Kazeto Y, Lokman PM. Fish Physiol Biochem 48 853-867 (2022)
- Identification of amino acid residues in the MT-loop of MT1-MMP critical for its ability to cleave low-density lipoprotein receptor. Wang M, Alabi A, Gu HM, Gill G, Zhang Z, Jarad S, Xia XD, Shen Y, Wang GQ, Zhang DW. Front Cardiovasc Med 9 917238 (2022)
- Impact of PCSK9 Immunization on Glycemic Indices in Diabetic Rats. Momtazi-Borojeni AA, Jaafari MR, Abdollahi E, Banach M, Sahebkar A. J Diabetes Res 2021 4757170 (2021)
- Large-Scale CRISPR Screen of LDLR Pathogenic Variants. Li M, Ma L, Chen Y, Li J, Wang Y, You W, Yuan H, Tang X, Ouyang H, Pang D. Research (Wash D C) 6 0203 (2023)
- Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis. Alabi A, Xia XD, Gu HM, Wang F, Deng SJ, Yang N, Adijiang A, Douglas DN, Kneteman NM, Xue Y, Chen L, Qin S, Wang G, Zhang DW. Nat Commun 12 1889 (2021)
- Multifunctional human monoclonal antibody combination mediates protection against Rift Valley fever virus at low doses. Chapman NS, Hulswit RJG, Westover JLB, Stass R, Paesen GC, Binshtein E, Reidy JX, Engdahl TB, Handal LS, Flores A, Gowen BB, Bowden TA, Crowe JE. Nat Commun 14 5650 (2023)
- NHE6 depletion corrects ApoE4-mediated synaptic impairments and reduces amyloid plaque load. Pohlkamp T, Xian X, Wong CH, Durakoglugil MS, Werthmann GC, Saido TC, Evers BM, White CL, Connor J, Hammer RE, Herz J. Elife 10 e72034 (2021)
- Novel LDLR variants affecting low density lipoprotein metabolism identified in familial hypercholesterolemia. Wang M, Hong L, Cai L, Zhang Z, Jiang N, Chen Y, Ying Q, Kong L, Wei Z, Xu Y, Jin L. Mol Biol Rep 51 153 (2024)
- PCSK9 acts as a key regulator of Aβ clearance across the blood-brain barrier. Mazura AD, Ohler A, Storck SE, Kurtyka M, Scharfenberg F, Weggen S, Becker-Pauly C, Pietrzik CU. Cell Mol Life Sci 79 212 (2022)
- PI(4,5)P2 and Cholesterol: Synthesis, Regulation, and Functions. Rosenhouse-Dantsker A, Gazgalis D, Logothetis DE. Adv Exp Med Biol 1422 3-59 (2023)
- Potential Link Between Proprotein Convertase Subtilisin/Kexin Type 9 and Alzheimer's Disease. Ce O, Rs P, Ab W, S D, Cj W, Qm M, D L. Int J Biomed Investig 1 (2018)
- Replacement of cysteine at position 46 in the first cysteine-rich repeat of the LDL receptor impairs apolipoprotein recognition. Benito-Vicente A, Uribe KB, Siddiqi H, Jebari S, Galicia-Garcia U, Larrea-Sebal A, Cenarro A, Stef M, Ostolaza H, Civeira F, Palacios L, Martin C. PLoS One 13 e0204771 (2018)
- Single molecule, long-read Apoer2 sequencing identifies conserved and species-specific splicing patterns. Gallo CM, Labadorf AT, Ho A, Beffert U. Genomics 114 110318 (2022)
- Soluble LDL-receptor is induced by TNF-α and inhibits hepatocytic clearance of LDL-cholesterol. Zegeye MM, Nakka SS, Andersson JSO, Söderberg S, Ljungberg LU, Kumawat AK, Sirsjö A. J Mol Med (Berl) 101 1615-1626 (2023)
- Synthesis of multi-module low density lipoprotein receptor class A domains with acid labile cyanopyridiniumylides (CyPY) as aspartic acid masking groups. Neumann K, Vujinovic A, Kamara S, Zwicky A, Baldauf S, Bode JW. RSC Chem Biol 4 292-299 (2023)