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Crystal structure of a human aminoacyl-tRNA synthetase cytokine

Source organism: Homo sapiens
Biochemical function: ATP binding
Biological process: tyrosyl-tRNA aminoacylation
Cellular component: not assigned

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EC 6.1.1.1: Tyrosine--tRNA ligase

Reaction catalysed:
ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr)
Systematic name:
L-tyrosine:tRNA(Tyr) ligase (AMP-forming)
Alternative Name(s):
  • L-tyrosine-tRNA(Tyr) ligase (AMP-forming)
  • Tyrosine tRNA synthetase
  • Tyrosine translase
  • Tyrosine-transfer RNA ligase
  • Tyrosine-transfer ribonucleate synthetase
  • Tyrosyl-tRNA ligase
  • Tyrosyl-tRNA synthetase
  • Tyrosyl-transfer RNA synthetase
  • Tyrosyl-transfer ribonucleate synthetase
  • Tyrosyl-transfer ribonucleic acid synthetase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00579
Domain description: tRNA synthetases class I (W and Y)
Occurring in:
  1. Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed
The deposited structure of PDB entry 1n3l contains 1 copy of Pfam domain PF00579 (tRNA synthetases class I (W and Y)) in Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002307
Domain description: Tyrosine-tRNA ligase
Occurring in:
  1. Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed
IPR002305
Domain description: Aminoacyl-tRNA synthetase, class Ic
Occurring in:
  1. Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed
IPR023617
Domain description: Tyrosine-tRNA ligase, archaeal/eukaryotic-type
Occurring in:
  1. Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed
IPR014729
Domain description: Rossmann-like alpha/beta/alpha sandwich fold
Occurring in:
  1. Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed

Structure domains

CATH CATH domains
1.10.240.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Tyrosyl-Transfer RNA Synthetase
Homology: Tyrosyl-Transfer RNA Synthetase
Occurring in:
  1. Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed
The deposited structure of PDB entry 1n3l contains 1 copy of CATH domain 1.10.240.10 (Tyrosyl-Transfer RNA Synthetase) in Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed. Showing 1 copy in chain A.
3.40.50.620
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: HUPs
Occurring in:
  1. Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed
The deposited structure of PDB entry 1n3l contains 1 copy of CATH domain 3.40.50.620 (Rossmann fold) in Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed. Showing 1 copy in chain A.
SCOP SCOP annotation
52375
Class: Alpha and beta proteins (a/b)
Fold: Adenine nucleotide alpha hydrolase-like
Superfamily: Nucleotidylyl transferase
Occurring in:
  1. Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed
The deposited structure of PDB entry 1n3l contains 1 copy of SCOP domain 52375 (Class I aminoacyl-tRNA synthetases (RS), catalytic domain) in Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed. Showing 1 copy in chain A.

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