X-ray diffraction
3.2Å resolution

Crystal structure of a covalent intermediate of endogenous human arylsulfatase A


Function and Biology Details

Reaction catalysed:
A cerebroside 3-sulfate + H(2)O = a cerebroside + sulfate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Arylsulfatase A Chain: A
Molecule details ›
Chain: A
Length: 489 amino acids
Theoretical weight: 52.04 KDa
Source organism: Homo sapiens
  • Canonical: P15289 (Residues: 19-507; Coverage: 100%)
Gene name: ARSA
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
2 bound ligands:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: I422
Unit cell:
a: 131.25Å b: 131.25Å c: 191.84Å
α: 90° β: 90° γ: 90°
R R work R free
0.216 0.182 0.223