1n26

X-ray diffraction
2.4Å resolution

Crystal Structure of the extra-cellular domains of Human Interleukin-6 Receptor alpha chain

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Soluble interleukin-6 receptor subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 325 amino acids
Theoretical weight: 36.41 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P08887 (Residues: 20-344; Coverage: 72%)
Gene name: IL6R
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN, NDG
Carbohydrate polymer : NEW Components: NAG
3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MACSCIENCE, RIGAKU RUH3R, APS BEAMLINE 14-BM-C, null
Spacegroup: P43212
Unit cell:
a: 51.13Å b: 51.13Å c: 303.388Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.22 0.29
Expression system: Cricetulus griseus