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Crystal structure of a RAD51-BRCA2 BRC repeat complex

Source organism: Homo sapiens
Biochemical function: ATP-dependent DNA damage sensor activity
Biological process: mitotic recombination-dependent replication fork processing
Cellular component: not assigned

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF00634
Domain description: BRCA2 repeat
Occurring in:
  1. Breast cancer type 2 susceptibility protein
The deposited structure of PDB entry 1n0w contains 1 copy of Pfam domain PF00634 (BRCA2 repeat) in Breast cancer type 2 susceptibility protein. Showing 1 copy in chain B.

PF08423
Domain description: Rad51
Occurring in:
  1. DNA repair protein RAD51 homolog 1
The deposited structure of PDB entry 1n0w contains 1 copy of Pfam domain PF08423 (Rad51) in DNA repair protein RAD51 homolog 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002093
Domain description: BRCA2 repeat
Occurring in:
  1. Breast cancer type 2 susceptibility protein
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. DNA repair protein RAD51 homolog 1
IPR020587
Domain description: DNA recombination and repair protein RecA, monomer-monomer interface
Occurring in:
  1. DNA repair protein RAD51 homolog 1
IPR003593
Domain description: AAA+ ATPase domain
Occurring in:
  1. DNA repair protein RAD51 homolog 1
IPR020588
Domain description: DNA recombination and repair protein RecA-like, ATP-binding domain
Occurring in:
  1. DNA repair protein RAD51 homolog 1
IPR011941
Domain description: DNA recombination/repair protein Rad51
Occurring in:
  1. DNA repair protein RAD51 homolog 1
IPR011939
Domain description: DNA repair and recombination protein RadB
Occurring in:
  1. DNA repair protein RAD51 homolog 1
IPR013632
Domain description: DNA recombination and repair protein Rad51-like, C-terminal
Occurring in:
  1. DNA repair protein RAD51 homolog 1

Structure domain

CATH CATH domain
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. DNA repair protein RAD51 homolog 1
The deposited structure of PDB entry 1n0w contains 1 copy of CATH domain 3.40.50.300 (Rossmann fold) in DNA repair protein RAD51 homolog 1. Showing 1 copy in chain A.
SCOP SCOP annotations
82987
Class: Peptides
Fold: BRCA2 BRC4 repeat
Superfamily: BRCA2 BRC4 repeat
Occurring in:
  1. Breast cancer type 2 susceptibility protein
The deposited structure of PDB entry 1n0w contains 1 copy of SCOP domain 82987 (BRCA2 BRC4 repeat) in Breast cancer type 2 susceptibility protein. Showing 1 copy in chain B.
52670
Class: Alpha and beta proteins (a/b)
Fold: P-loop containing nucleoside triphosphate hydrolases
Superfamily: P-loop containing nucleoside triphosphate hydrolases
Occurring in:
  1. DNA repair protein RAD51 homolog 1
The deposited structure of PDB entry 1n0w contains 1 copy of SCOP domain 52670 (RecA protein-like (ATPase-domain)) in DNA repair protein RAD51 homolog 1. Showing 1 copy in chain A.

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