Function and Biology

Structure of p18INK4c (F92N)

Source organism: Homo sapiens
Biochemical function: protein kinase binding
Biological process: negative regulation of stem cell proliferation
Cellular component: cytosol

Sequence family

Pfam Protein family (Pfam)
PF12796
Domain description: Ankyrin repeats (3 copies)
Occurring in:
  1. Cyclin-dependent kinase 4 inhibitor C
The deposited structure of PDB entry 1mx6 contains 4 copies of Pfam domain PF12796 (Ankyrin repeats (3 copies)) in Cyclin-dependent kinase 4 inhibitor C. Showing 2 copies in chain A.

InterPro InterPro annotations
IPR002110
Domain description: Ankyrin repeat
Occurring in:
  1. Cyclin-dependent kinase 4 inhibitor C
IPR036770
Domain description: Ankyrin repeat-containing domain superfamily
Occurring in:
  1. Cyclin-dependent kinase 4 inhibitor C

Structure domain

CATH CATH domain
1.25.40.20
Class: Mainly Alpha
Architecture: Alpha Horseshoe
Topology: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Homology: Ankyrin repeat-containing domain
Occurring in:
  1. Cyclin-dependent kinase 4 inhibitor C
The deposited structure of PDB entry 1mx6 contains 2 copies of CATH domain 1.25.40.20 (Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat) in Cyclin-dependent kinase 4 inhibitor C. Showing 1 copy in chain A.
SCOP SCOP annotation
48404
Class: Alpha and beta proteins (a+b)
Fold: beta-hairpin-alpha-hairpin repeat
Superfamily: Ankyrin repeat
Occurring in:
  1. Cyclin-dependent kinase 4 inhibitor C
The deposited structure of PDB entry 1mx6 contains 2 copies of SCOP domain 48404 (Ankyrin repeat) in Cyclin-dependent kinase 4 inhibitor C. Showing 1 copy in chain A.