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Crystal Structure of a Smad4-Ski Complex

Source organism: Homo sapiens
Biochemical function: SMAD binding
Biological process: regulation of DNA-templated transcription
Cellular component: not assigned

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GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF08782
Domain description: c-SKI Smad4 binding domain
Occurring in:
  1. Ski oncogene
The deposited structure of PDB entry 1mr1 contains 2 copies of Pfam domain PF08782 (c-SKI Smad4 binding domain) in Ski oncogene. Showing 1 copy in chain C.

PF03166
Domain description: MH2 domain
Occurring in:
  1. Mothers against decapentaplegic homolog 4
The deposited structure of PDB entry 1mr1 contains 2 copies of Pfam domain PF03166 (MH2 domain) in Mothers against decapentaplegic homolog 4. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR014890
Domain description: c-SKI SMAD4-binding domain
Occurring in:
  1. Ski oncogene
IPR010919
Domain description: SAND-like domain superfamily
Occurring in:
  1. Ski oncogene
IPR001132
Domain description: SMAD domain, Dwarfin-type
Occurring in:
  1. Mothers against decapentaplegic homolog 4
IPR023216
Domain description: Transcription regulator SKI/SnoN
Occurring in:
  1. Ski oncogene
IPR013790
Domain description: Dwarfin
Occurring in:
  1. Mothers against decapentaplegic homolog 4
IPR008984
Domain description: SMAD/FHA domain superfamily
Occurring in:
  1. Mothers against decapentaplegic homolog 4
IPR017855
Domain description: SMAD-like domain superfamily
Occurring in:
  1. Mothers against decapentaplegic homolog 4

Structure domains

CATH CATH domains
3.10.390.10
Class: Alpha Beta
Architecture: Roll
Topology: SAND domain
Homology: SAND domain-like
Occurring in:
  1. Ski oncogene
The deposited structure of PDB entry 1mr1 contains 2 copies of CATH domain 3.10.390.10 (SAND domain) in Ski oncogene. Showing 1 copy in chain C.
2.60.200.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Tumour Suppressor Smad4
Homology: Tumour Suppressor Smad4
Occurring in:
  1. Mothers against decapentaplegic homolog 4
The deposited structure of PDB entry 1mr1 contains 2 copies of CATH domain 2.60.200.10 (Tumour Suppressor Smad4) in Mothers against decapentaplegic homolog 4. Showing 1 copy in chain A.
SCOP SCOP annotations
82611
Class: Alpha and beta proteins (a+b)
Fold: SAND domain-like
Superfamily: SAND domain-like
Occurring in:
  1. Ski oncogene
The deposited structure of PDB entry 1mr1 contains 2 copies of SCOP domain 82611 (SMAD4-binding domain of oncoprotein Ski) in Ski oncogene. Showing 1 copy in chain C.
49880
Class: All beta proteins
Fold: SMAD/FHA domain
Superfamily: SMAD/FHA domain
Occurring in:
  1. Mothers against decapentaplegic homolog 4
The deposited structure of PDB entry 1mr1 contains 2 copies of SCOP domain 49880 (SMAD domain) in Mothers against decapentaplegic homolog 4. Showing 1 copy in chain A.

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