› 1mqi

X-ray diffraction
1.35Å resolution

Crystal Structure of the GluR2 Ligand Binding Core (S1S2J) in Complex with Fluoro-Willardiine at 1.35 Angstroms Resolution

Released:
DOI: 10.2210/pdb1mqi/pdb
PDB 1mqi coloured by chain and viewed from the front.
PDB 1mqi coloured by chain and viewed from the side.
PDB 1mqi coloured by chain and viewed from the top.
Source organism: Rattus norvegicus
Primary publication:
Structural basis for partial agonist action at ionotropic glutamate receptors.
Jin R, Banke TG, Mayer ML, Traynelis SF, Gouaux E
Nat Neurosci 6 803-10 (2003)
PMID: 12872125

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 263 amino acids
Theoretical weight: 29.22 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P19491 (Residues: 413-527, 653-796; Coverage: 30%)
Gene names: Glur2, Gria2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

1 bound ligand:
Ligand FWD 1 x FWD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P21212
Unit cell:
a: 63.913Å b: 91.431Å c: 48.286Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.2 0.218
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

44 review citations

Interplay between Gating and Block of Ligand-Gated Ion Channels.
Phillips et al. (2020)
43 more

4 mentions without citation

Structure and dynamics of AMPA receptor GluA2 in resting, pre-open, and desensitized states.
Dürr et al. (2014)
3 more