Reviews - 1mq7 mentioned but not cited (1)
- Predictive Power of In Silico Approach to Evaluate Chemicals against M. tuberculosis: A Systematic Review. Timo GO, Reis RSSVD, Melo AF, Costa TVL, Magalhães PO, Homem-de-Mello M. Pharmaceuticals (Basel) 12 E135 (2019)
Articles - 1mq7 mentioned but not cited (3)
- Structure and activity of the Saccharomyces cerevisiae dUTP pyrophosphatase DUT1, an essential housekeeping enzyme. Tchigvintsev A, Singer AU, Flick R, Petit P, Brown G, Evdokimova E, Savchenko A, Yakunin AF. Biochem J 437 243-253 (2011)
- Direct contacts between conserved motifs of different subunits provide major contribution to active site organization in human and mycobacterial dUTPases. Takács E, Nagy G, Leveles I, Harmat V, Lopata A, Tóth J, Vértessy BG. FEBS Lett 584 3047-3054 (2010)
- The Bacteriophage-Phage-Inducible Chromosomal Island Arms Race Designs an Interkingdom Inhibitor of dUTPases. Sanz-Frasquet C, Ciges-Tomas JR, Alite C, Penadés JR, Marina A. Microbiol Spectr 11 e0323222 (2023)
Reviews citing this publication (6)
- The phage-related chromosomal islands of Gram-positive bacteria. Novick RP, Christie GE, Penadés JR. Nat Rev Microbiol 8 541-551 (2010)
- DNA base damage recognition and removal: new twists and grooves. Huffman JL, Sundheim O, Tainer JA. Mutat Res 577 55-76 (2005)
- DNA repair in Mycobacterium tuberculosis revisited. Dos Vultos T, Mestre O, Tonjum T, Gicquel B. FEMS Microbiol Rev 33 471-487 (2009)
- Preventive DNA repair by sanitizing the cellular (deoxy)nucleoside triphosphate pool. Nagy GN, Leveles I, Vértessy BG. FEBS J 281 4207-4223 (2014)
- dUTPase: the frequently overlooked enzyme encoded by many retroviruses. Hizi A, Herzig E. Retrovirology 12 70 (2015)
- dUTPases, the unexplored family of signalling molecules. Penadés JR, Donderis J, García-Caballer M, Tormo-Más MÁ, Marina A. Curr Opin Microbiol 16 163-170 (2013)
Articles citing this publication (39)
- Keeping uracil out of DNA: physiological role, structure and catalytic mechanism of dUTPases. Vértessy BG, Tóth J. Acc Chem Res 42 97-106 (2009)
- House cleaning, a part of good housekeeping. Galperin MY, Moroz OV, Wilson KS, Murzin AG. Mol Microbiol 59 5-19 (2006)
- Moonlighting bacteriophage proteins derepress staphylococcal pathogenicity islands. Tormo-Más MA, Mir I, Shrestha A, Tallent SM, Campoy S, Lasa I, Barbé J, Novick RP, Christie GE, Penadés JR. Nature 465 779-782 (2010)
- Structures of DNA polymerase beta with active-site mismatches suggest a transient abasic site intermediate during misincorporation. Batra VK, Beard WA, Shock DD, Pedersen LC, Wilson SH. Mol Cell 30 315-324 (2008)
- Active site of mycobacterial dUTPase: structural characteristics and a built-in sensor. Varga B, Barabás O, Takács E, Nagy N, Nagy P, Vértessy BG. Biochem Biophys Res Commun 373 8-13 (2008)
- The monomeric dUTPase from Epstein-Barr virus mimics trimeric dUTPases. Tarbouriech N, Buisson M, Seigneurin JM, Cusack S, Burmeister WP. Structure 13 1299-1310 (2005)
- The dUTPase enzyme is essential in Mycobacterium smegmatis. Pecsi I, Hirmondo R, Brown AC, Lopata A, Parish T, Vertessy BG, Tóth J. PLoS One 7 e37461 (2012)
- Aromatic stacking between nucleobase and enzyme promotes phosphate ester hydrolysis in dUTPase. Pecsi I, Leveles I, Harmat V, Vertessy BG, Toth J. Nucleic Acids Res 38 7179-7186 (2010)
- An introduction to biomolecular graphics. Mura C, McCrimmon CM, Vertrees J, Sawaya MR. PLoS Comput Biol 6 e1000918 (2010)
- Nucleotide pyrophosphatase employs a P-loop-like motif to enhance catalytic power and NDP/NTP discrimination. Pécsi I, Szabó JE, Adams SD, Simon I, Sellers JR, Vértessy BG, Tóth J. Proc Natl Acad Sci U S A 108 14437-14442 (2011)
- Methylene substitution at the alpha-beta bridging position within the phosphate chain of dUDP profoundly perturbs ligand accommodation into the dUTPase active site. Kovári J, Barabás O, Varga B, Békési A, Tölgyesi F, Fidy J, Nagy J, Vértessy BG. Proteins 71 308-319 (2008)
- The flexible motif V of Epstein-Barr virus deoxyuridine 5'-triphosphate pyrophosphatase is essential for catalysis. Freeman L, Buisson M, Tarbouriech N, Van der Heyden A, Labbé P, Burmeister WP. J Biol Chem 284 25280-25289 (2009)
- Molecular basis of the antimutagenic activity of the house-cleaning inosine triphosphate pyrophosphatase RdgB from Escherichia coli. Savchenko A, Proudfoot M, Skarina T, Singer A, Litvinova O, Sanishvili R, Brown G, Chirgadze N, Yakunin AF. J Mol Biol 374 1091-1103 (2007)
- Structure and enzymatic mechanism of a moonlighting dUTPase. Leveles I, Németh V, Szabó JE, Harmat V, Nyíri K, Bendes ÁÁ, Papp-Kádár V, Zagyva I, Róna G, Ozohanics O, Vékey K, Tóth J, Vértessy BG. Acta Crystallogr D Biol Crystallogr 69 2298-2308 (2013)
- Crystal Structure of African Swine Fever Virus dUTPase Reveals a Potential Drug Target. Li C, Chai Y, Song H, Weng C, Qi J, Sun Y, Gao GF. mBio 10 e02483-19 (2019)
- Cross-species inhibition of dUTPase via the Staphylococcal Stl protein perturbs dNTP pool and colony formation in Mycobacterium. Hirmondó R, Szabó JE, Nyíri K, Tarjányi S, Dobrotka P, Tóth J, Vértessy BG. DNA Repair (Amst) 30 21-27 (2015)
- Mechanism of dTTP inhibition of the bifunctional dCTP deaminase:dUTPase encoded by Mycobacterium tuberculosis. Helt SS, Thymark M, Harris P, Aagaard C, Dietrich J, Larsen S, Willemoes M. J Mol Biol 376 554-569 (2008)
- On the catalytic mechanism of dimeric dUTPases. Hemsworth GR, González-Pacanowska D, Wilson KS. Biochem J 456 81-88 (2013)
- Structural and functional insights into DR2231 protein, the MazG-like nucleoside triphosphate pyrophosphohydrolase from Deinococcus radiodurans. Gonçalves AMD, de Sanctis D, McSweeney SM. J Biol Chem 286 30691-30705 (2011)
- Molecular modeling of Mycobacterium tuberculosis dUTpase: docking and catalytic mechanism studies. Ramalho TC, Caetano MS, Josa D, Luz GP, Freitas EA, da Cunha EF. J Biomol Struct Dyn 28 907-917 (2011)
- CRISPR/Cas9-Mediated Knock-Out of dUTPase in Mice Leads to Early Embryonic Lethality. Pálinkás HL, Rácz GA, Gál Z, Hoffmann OI, Tihanyi G, Róna G, Gócza E, Hiripi L, Vértessy BG. Biomolecules 9 E136 (2019)
- Catalytic mechanism of α-phosphate attack in dUTPase is revealed by X-ray crystallographic snapshots of distinct intermediates, 31P-NMR spectroscopy and reaction path modelling. Barabás O, Németh V, Bodor A, Perczel A, Rosta E, Kele Z, Zagyva I, Szabadka Z, Grolmusz VI, Wilmanns M, Vértessy BG. Nucleic Acids Res 41 10542-10555 (2013)
- Regulation of dCTP deaminase from Escherichia coli by nonallosteric dTTP binding to an inactive form of the enzyme. Johansson E, Thymark M, Bynck JH, Fanø M, Larsen S, Willemoës M. FEBS J 274 4188-4198 (2007)
- Structural Insight into African Swine Fever Virus dUTPase Reveals a Novel Folding Pattern in the dUTPase Family. Li G, Wang C, Yang M, Cao L, Fu D, Liu X, Sun D, Chen C, Wang Y, Jia Z, Yang C, Guo Y, Rao Z. J Virol 94 e01698-19 (2020)
- The dUTPase-related gene of bovine immunodeficiency virus is critical for viral replication, despite the lack of dUTPase activity of the encoded protein. Voronin N, Herzig E, Hizi A. Retrovirology 11 60 (2014)
- Deletion of the ASFV dUTPase Gene E165R from the Genome of Highly Virulent African Swine Fever Virus Georgia 2010 Does Not Affect Virus Replication or Virulence in Domestic Pigs. Vuono EA, Ramirez-Medina E, Pruitt S, Rai A, Espinoza N, Silva E, Velazquez-Salinas L, Gladue DP, Borca MV. Viruses 14 1409 (2022)
- RepTB: a gene ontology based drug repurposing approach for tuberculosis. Passi A, Rajput NK, Wild DJ, Bhardwaj A. J Cheminform 10 24 (2018)
- The structure of the genomic Bacillus subtilis dUTPase: novel features in the Phe-lid. García-Nafría J, Burchell L, Takezawa M, Rzechorzek NJ, Fogg MJ, Wilson KS. Acta Crystallogr D Biol Crystallogr 66 953-961 (2010)
- Tying down the arm in Bacillus dUTPase: structure and mechanism. García-Nafría J, Timm J, Harrison C, Turkenburg JP, Wilson KS. Acta Crystallogr D Biol Crystallogr 69 1367-1380 (2013)
- A Hidden Active Site in the Potential Drug Target Mycobacterium tuberculosis dUTPase Is Accessible through Small Amplitude Protein Conformational Changes. Lopata A, Leveles I, Bendes ÁÁ, Viskolcz B, Vértessy BG, Jójárt B, Tóth J. J Biol Chem 291 26320-26331 (2016)
- Comparison of the Efficacy of Two Novel Antitubercular Agents in Free and Liposome-Encapsulated Formulations. Kósa N, Zolcsák Á, Voszka I, Csík G, Horváti K, Horváth L, Bősze S, Herenyi L. Int J Mol Sci 22 2457 (2021)
- Design, synthesis and evaluation of novel uracil amino acid conjugates for the inhibition of Trypanosoma cruzi dUTPase. Mc Carthy OK, Schipani A, Buendía AM, Ruiz-Perez LM, Kaiser M, Brun R, Pacanowska DG, Gilbert IH. Bioorg Med Chem Lett 16 3809-3812 (2006)
- Identification and Characterization of a Novel Epitope of ASFV-Encoded dUTPase by Monoclonal Antibodies. Zhang S, Wang R, Zhu X, Jin J, Lu W, Zhao X, Wan B, Liao Y, Zhao Q, Netherton CL, Zhuang G, Sun A, Zhang G. Viruses 13 2175 (2021)
- Site-directed mutagenesis provides insights into the selective binding of trityl derivatives to Plasmodium falciparum dUTPase. Recio E, Musso-Buendía A, Vidal AE, Ruda GF, Kasinathan G, Nguyen C, Ruiz-Pérez LM, Gilbert IH, González-Pacanowska D. Eur J Med Chem 46 3309-3314 (2011)
- Concerted bifunctionality of the dCTP deaminase-dUTPase from Methanocaldococcus jannaschii: a structural and pre-steady state kinetic analysis. Siggaard JH, Johansson E, Vognsen T, Helt SS, Harris P, Larsen S, Willemoës M. Arch Biochem Biophys 490 42-49 (2009)
- Methylene analogues of adenosine 5'-tetraphosphate. Their chemical synthesis and recognition by human and plant mononucleoside tetraphosphatases and dinucleoside tetraphosphatases. Guranowski A, Starzyńska E, Pietrowska-Borek M, Jemielity J, Kowalska J, Darzynkiewicz E, Thompson MJ, Blackburn GM. FEBS J 273 829-838 (2006)
- Backbone nuclear magnetic resonance assignment of human deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase). Isaksson J, Woestenenk E, Sahlberg C, Agback T. Biomol NMR Assign 8 81-84 (2014)
- Redox status of cysteines does not alter functional properties of human dUTPase but the Y54C mutation involved in monogenic diabetes decreases protein stability. Szabó JE, Nyíri K, Andrási D, Matejka J, Ozohanics O, Vértessy B. Sci Rep 11 19197 (2021)
- Screening and Identification of a Novel Anti-tuberculosis Compound That Targets Deoxyuridine 5'-Triphosphate Nucleotidohydrolase. Zhang Y, Zhang H, Chen Y, Qiao L, Han Y, Lin Y, Si S, Jiang JD. Front Microbiol 12 757914 (2021)
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- HUMAN DUTP PYROPHOSPHATASE: URACIL RECOGNITION BY A BETA HAIRPIN AND ACTIVE SITES FORMED BY THREE SEPARATE SUBUNITS. Mol CD, Harris JM, Mclntosh EM, Tainer JA Structure 4 1077-1092 (1996)