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Structure of the Neurospora SET domain protein DIM-5, a histone lysine methyltransferase

Source organism: Neurospora crassa
Biochemical function: histone H3K9 trimethyltransferase activity
Biological process: methylation
Cellular component: chromosome

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EC 2.1.1.355: [Histone H3]-lysine(9) N-trimethyltransferase

Reaction catalysed:
(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine(9) = S-adenosyl-L-homocysteine + a [histone H3]-N(6)-methyl-L-lysine(9)
Systematic name:
S-adenosyl-L-methionine:[histone H3]-L-lysine(9) N(6)-methyltransferase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00856
Domain description: SET domain
Occurring in:
  1. Histone-lysine N-methyltransferase, H3 lysine-9 specific dim-5
The deposited structure of PDB entry 1ml9 contains 1 copy of Pfam domain PF00856 (SET domain) in Histone-lysine N-methyltransferase, H3 lysine-9 specific dim-5. Showing 1 copy in chain A.

PF05033
Domain description: Pre-SET motif
Occurring in:
  1. Histone-lysine N-methyltransferase, H3 lysine-9 specific dim-5
The deposited structure of PDB entry 1ml9 contains 1 copy of Pfam domain PF05033 (Pre-SET motif) in Histone-lysine N-methyltransferase, H3 lysine-9 specific dim-5. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001214
Domain description: SET domain
Occurring in:
  1. Histone-lysine N-methyltransferase, H3 lysine-9 specific dim-5
IPR007728
Domain description: Pre-SET domain
Occurring in:
  1. Histone-lysine N-methyltransferase, H3 lysine-9 specific dim-5
IPR046341
Domain description: SET domain superfamily
Occurring in:
  1. Histone-lysine N-methyltransferase, H3 lysine-9 specific dim-5
IPR003616
Domain description: Post-SET domain
Occurring in:
  1. Histone-lysine N-methyltransferase, H3 lysine-9 specific dim-5

Structure domain

CATH CATH domain
2.170.270.10
Class: Mainly Beta
Architecture: Beta Complex
Topology: Beta-clip-like
Homology: SET domain
Occurring in:
  1. Histone-lysine N-methyltransferase, H3 lysine-9 specific dim-5
The deposited structure of PDB entry 1ml9 contains 1 copy of CATH domain 2.170.270.10 (Beta-clip-like) in Histone-lysine N-methyltransferase, H3 lysine-9 specific dim-5. Showing 1 copy in chain A.
SCOP SCOP annotation
82200
Class: All beta proteins
Fold: beta-clip
Superfamily: SET domain
Occurring in:
  1. Histone-lysine N-methyltransferase, H3 lysine-9 specific dim-5
The deposited structure of PDB entry 1ml9 contains 1 copy of SCOP domain 82200 (Histone lysine methyltransferases) in Histone-lysine N-methyltransferase, H3 lysine-9 specific dim-5. Showing 1 copy in chain A.

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