› 1mju

X-ray diffraction
1.22Å resolution

1.22 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF ESTEROLYTIC ANTIBODY MS6-12

Released:
DOI: 10.2210/pdb1mju/pdb
PDB 1mju coloured by chain and viewed from the front.
PDB 1mju coloured by chain and viewed from the side.
PDB 1mju coloured by chain and viewed from the top.
Source organism: Mus musculus
Primary publication:
High-resolution crystal structure of the Fab-fragments of a family of mouse catalytic antibodies with esterase activity.
Ruzheinikov SN, Muranova TA, Sedelnikova SE, Partridge LJ, Blackburn GM, Murray IA, Kakinuma H, Takahashi-Ando N, Shimazaki K, Sun J, Nishi Y, Rice DW
J Mol Biol 332 423-35 (2003)
PMID: 12948492

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
IMMUNOGLOBULIN MS6-12 Chain: L
Molecule details ›
Chain: L
Length: 219 amino acids
Theoretical weight: 24.19 KDa
Source organism: Mus musculus
Expression system: Mus musculus
Structure domains: Immunoglobulins
IMMUNOGLOBULIN MS6-12 Chain: H
Molecule details ›
Chain: H
Length: 227 amino acids
Theoretical weight: 24.37 KDa
Source organism: Mus musculus
Expression system: Mus musculus
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand GOL 6 x GOL
1 modified residue:
Ligand PCA 1 x PCA

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX9.6
Spacegroup: P212121
Unit cell:
a: 56.046Å b: 65.349Å c: 138.563Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.124 0.123 0.154
Expression system: Mus musculus

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Citations

1 review citation

Antibody structure, instability, and formulation.
Wang et al. (2007)
7 other articles

4 mentions without citation

A new clustering of antibody CDR loop conformations.
North et al. (2011)
3 more