› 1mj7

X-ray diffraction
2.25Å resolution

Crystal Structure Of The Complex Of The Fab fragment of Esterolytic Antibody MS5-393 and A Transition-State Analog

Released:
DOI: 10.2210/pdb1mj7/pdb
PDB entry 1mj7 coloured by chain, front view.
PDB entry 1mj7 coloured by chain, side view.
PDB entry 1mj7 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
High-resolution crystal structure of the Fab-fragments of a family of mouse catalytic antibodies with esterase activity.
Ruzheinikov SN, Muranova TA, Sedelnikova SE, Partridge LJ, Blackburn GM, Murray IA, Kakinuma H, Takahashi-Ando N, Shimazaki K, Sun J, Nishi Y, Rice DW
J Mol Biol 332 423-35 (2003)
PMID: 12948492

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-213047 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
IMMUNOGLOBULIN MS5-393 Chain: L
Molecule details ›
Chain: L
Length: 219 amino acids
Theoretical weight: 24.25 KDa
Source organism: Mus musculus
Expression system: Mus musculus
Structure domains: Immunoglobulins
IMMUNOGLOBULIN MS5-393 Chain: H
Molecule details ›
Chain: H
Length: 228 amino acids
Theoretical weight: 24.49 KDa
Source organism: Mus musculus
Expression system: Mus musculus
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand HAL 1 x HAL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX14.2
Spacegroup: C2
Unit cell:
a: 128.237Å b: 40.531Å c: 85.903Å
α: 90° β: 109.72° γ: 90°
R-values:
R R work R free
0.2 0.2 0.303
Expression system: Mus musculus

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Citations

1 review citation

Antibody structure, instability, and formulation.
Wang et al. (2007)
9 other articles