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Crystal structure of an integrin beta3-talin chimera

X-ray diffraction
1.9Å resolution
PDB entry 1miz coloured by chain, front view.
PDB entry 1miz coloured by chain, side view.
PDB entry 1miz coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Integrin beta-3 and Talin-1
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Multimeric state: hetero dimer
Accessible surface area: 13304.94 Å2
Buried surface area: 274.81 Å2
Dissociation area: 137.41 Å2
Dissociation energy (ΔGdiss): -6.68 kcal/mol
Dissociation entropy (TΔSdiss): 6.82 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-138489

Macromolecules

Integrin beta-3
Chain: A
Length: 9 amino acids
Theoretical weight: 959 Da
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P05106 (Residues: 765-769; Coverage: 1%)
Gene names: GP3A, ITGB3
Integrin beta-3 in PDB entry 1miz, assembly 1, front view.
Integrin beta-3 in PDB entry 1miz, assembly 1, side view.
Integrin beta-3 in PDB entry 1miz, assembly 1, top view.
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Talin-1
Chain: B
Length: 201 amino acids
Theoretical weight: 23.17 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P54939 (Residues: 200-400; Coverage: 8%)
Gene names: TLN, TLN1
Pfam: FERM central domain
InterPro:
CATH:
SCOP:
Talin-1 in PDB entry 1miz, assembly 1, front view.
Talin-1 in PDB entry 1miz, assembly 1, side view.
Talin-1 in PDB entry 1miz, assembly 1, top view.
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