› 1mhc

X-ray diffraction
2.1Å resolution

MODEL OF MHC CLASS I H2-M3 WITH NONAPEPTIDE FROM RAT ND1 REFINED AT 2.3 ANGSTROMS RESOLUTION

Released:
DOI: 10.2210/pdb1mhc/pdb
PDB entry 1mhc coloured by chain, front view.
PDB entry 1mhc coloured by chain, side view.
PDB entry 1mhc coloured by chain, top view.
Source organisms:
Primary publication:
Nonclassical binding of formylated peptide in crystal structure of the MHC class Ib molecule H2-M3.
Wang CR, Castaño AR, Peterson PA, Slaughter C, Lindahl KF, Deisenhofer J
Cell 82 655-64 (1995)
PMID: 7664344

Function and Biology Details

Reaction catalysed: 
NADH + ubiquinone + 5 H(+)(Side 1) = NAD(+) + ubiquinol + 4 H(+)(Side 2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assemblies composition:
hetero trimer (preferred)
hetero hexamer
PDBe Complex ID:
PDB-CPX-135071 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ig-like domain-containing protein Chains: A, D
Molecule details ›
Chains: A, D
Length: 282 amino acids
Theoretical weight: 32.65 KDa
Source organism: Mus musculus
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q31093 (Residues: 25-298; Coverage: 88%)
Gene names: H-2M3, H2-M3
Sequence domains:
Structure domains:
Beta-2-microglobulin Chains: B, E
Molecule details ›
Chains: B, E
Length: 99 amino acids
Theoretical weight: 11.7 KDa
Source organism: Mus musculus
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P01887 (Residues: 21-119; Coverage: 100%)
Gene name: B2m
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
NADH-ubiquinone oxidoreductase chain 1 Chains: C, F
Molecule details ›
Chains: C, F
Length: 9 amino acids
Theoretical weight: 1.16 KDa
Source organism: Rattus rattus
Expression system: Not provided
UniProt:
  • Canonical: P03889 (Residues: 1-9; Coverage: 3%)
Gene names: Mt-nd1, Mtnd1, Nd1

Ligands and Environments

1 bound ligand:
Ligand NAG 1 x NAG
1 modified residue:
Ligand FME 2 x FME

Experiments and Validation Details

Entry percentile scores
Spacegroup: P1
Unit cell:
a: 65.25Å b: 66.1Å c: 55.17Å
α: 102.71° β: 96.28° γ: 110.19°
R-values:
R R work R free
0.19 0.19 not available
Expression systems:
  • Drosophila melanogaster
  • Not provided

Quick links

Citations

35 review citations

Mechanisms of MHC class I--restricted antigen processing.
Pamer et al. (1998)
34 more

4 mentions without citation

Recognition of a virus-encoded ligand by a natural killer cell activation receptor.
Smith et al. (2002)
3 more