X-ray diffraction
2.2Å resolution

Inosine Monophosphate Dehydrogenase (IMPDH) From Tritrichomonas Foetus with XMP and mycophenolic acid bound


Function and Biology Details

Reaction catalysed:
Inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADH
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Inosine-5'-monophosphate dehydrogenase Chain: A
Molecule details ›
Chain: A
Length: 503 amino acids
Theoretical weight: 55.54 KDa
Source organism: Tritrichomonas suis
Expression system: Escherichia coli
  • Canonical: P50097 (Residues: 1-503; Coverage: 100%)
Gene name: IMPDH
Sequence domains:
Structure domains: Aldolase class I

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: P432
Unit cell:
a: 155.07Å b: 155.07Å c: 155.07Å
α: 90° β: 90° γ: 90°
R R work R free
0.227 0.227 0.257
Expression system: Escherichia coli