1mcw

X-ray diffraction
3.5Å resolution

THREE-DIMENSIONAL STRUCTURE OF A HYBRID LIGHT CHAIN DIMER. PROTEIN ENGINEERING OF A BINDING CAVITY

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
IMMUNOGLOBULIN WEIR (LIGHT CHAIN) Chain: W
Molecule details ›
Chain: W
Length: 216 amino acids
Theoretical weight: 22.91 KDa
Source organism: Homo sapiens
Structure domains: Immunoglobulins
Immunoglobulin lambda variable 2-8 Chain: M
Molecule details ›
Chain: M
Length: 216 amino acids
Theoretical weight: 22.83 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01709 (Residues: 20-118; Coverage: 100%)
Gene name: IGLV2-8
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
1 modified residue:

Experiments and Validation Details

Entry percentile scores
Spacegroup: P3121
Unit cell:
a: 72.3Å b: 72.3Å c: 185.9Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.17 not available not available