1mah

X-ray diffraction
3.2Å resolution

FASCICULIN2-MOUSE ACETYLCHOLINESTERASE COMPLEX

Released:

Function and Biology Details

Reaction catalysed:
Acetylcholine + H(2)O = choline + acetate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Acetylcholinesterase Chain: A
Molecule details ›
Chain: A
Length: 543 amino acids
Theoretical weight: 59.76 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: P21836 (Residues: 32-574; Coverage: 93%)
Gene name: Ache
Sequence domains: Carboxylesterase family
Structure domains: alpha/beta hydrolase
Fasciculin-2 Chain: F
Molecule details ›
Chain: F
Length: 61 amino acids
Theoretical weight: 6.77 KDa
Source organism: Dendroaspis angusticeps
UniProt:
  • Canonical: P0C1Z0 (Residues: 1-61; Coverage: 100%)
Structure domains: CD59

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12C
Spacegroup: P6522
Unit cell:
a: 75.5Å b: 75.5Å c: 556.2Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.184 0.184 0.294
Expression system: Homo sapiens