X-ray diffraction
1.73Å resolution

X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type H87A,A88M Complex.


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Peptidyl-prolyl cis-trans isomerase A Chains: A, B
Molecule details ›
Chains: A, B
Length: 165 amino acids
Theoretical weight: 18.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P62937 (Residues: 1-165; Coverage: 100%)
Gene names: CYPA, PPIA
Sequence domains: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Structure domains: Cyclophilin-like
HIV-1 Capsid Chains: C, D
Molecule details ›
Chains: C, D
Length: 146 amino acids
Theoretical weight: 16.2 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q72497 (Residues: 133-278; Coverage: 29%)
Gene name: gag
Structure domains: Human Immunodeficiency Virus Type 1 Capsid Protein

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P21
Unit cell:
a: 38.508Å b: 110.941Å c: 67.932Å
α: 90° β: 101.41° γ: 90°
R R work R free
0.172 0.167 0.22
Expression system: Escherichia coli BL21(DE3)