PDBe 1m6b

X-ray diffraction
2.6Å resolution

Structure of the HER3 (ERBB3) Extracellular Domain

Source organism: Homo sapiens
Primary publication:
Structure of the extracellular region of HER3 reveals an interdomain tether.
Science 297 1330-3 (2002)
PMID: 12154198

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Receptor tyrosine-protein kinase erbB-3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 621 amino acids
Theoretical weight: 68.38 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
  • Canonical: P21860 (Residues: 20-640; Coverage: 47%)
Gene names: ERBB3, HER3
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: C2
Unit cell:
a: 236.26Å b: 49.62Å c: 190.86Å
α: 90° β: 125.56° γ: 90°
R R work R free
0.238 0.235 0.294
Expression system: Cricetulus griseus