1m4r

X-ray diffraction
2Å resolution

CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-22

Released:
Source organism: Homo sapiens
Entry authors: Nagem RAP, Colau D, Dumoutier L, Renauld J-C, Ogata C, Polikarpov I

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-22 Chains: A, B
Molecule details ›
Chains: A, B
Length: 151 amino acids
Theoretical weight: 17.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9GZX6 (Residues: 29-179; Coverage: 100%)
Gene names: IL22, ILTIF, UNQ3099/PRO10096, ZCYTO18
Sequence domains: Interleukin 22 IL-10-related T-cell-derived-inducible factor
Structure domains: Growth Hormone; Chain: A;

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LNLS BEAMLINE D03B-MX1
Spacegroup: P212121
Unit cell:
a: 55.43Å b: 61.61Å c: 73.47Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.188 0.22
Expression system: Escherichia coli