Solution NMR

Structure of the Tsg101 UEV domain in complex with a HIV-1 PTAP "late domain" peptide, DYANA Ensemble


Function and Biology Details

Biochemical function:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
Non-polymer only dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tumor susceptibility gene 101 protein Chain: A
Molecule details ›
Chain: A
Length: 145 amino acids
Theoretical weight: 16.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q99816 (Residues: 1-145; Coverage: 37%)
Gene name: TSG101
Sequence domains: UEV domain
Structure domains: Ubiquitin Conjugating Enzyme
Gag_p6 domain-containing protein Chain: B
Molecule details ›
Chain: B
Length: 9 amino acids
Theoretical weight: 966 Da
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q9IF21 (Residues: 27-35; Coverage: 13%)
Gene name: pol

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 85%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli BL21(DE3)