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Nitrogenase MoFe protein from Azotobacter vinelandii

Source organism: Azotobacter vinelandii
Biochemical function: iron-sulfur cluster binding
Biological process: nitrogen fixation
Cellular component: molybdenum-iron nitrogenase complex

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EC 1.18.6.1: Nitrogenase

Reaction catalysed:
8 reduced ferredoxin + 8 H(+) + N(2) + 16 ATP + 16 H(2)O = 8 oxidized ferredoxin + H(2) + 2 NH(3) + 16 ADP + 16 phosphate
Systematic name:
Ferredoxin:dinitrogen oxidoreductase (ATP-hydrolyzing, molybdenum-dependent)
Alternative Name(s):
  • Reduced ferredoxin:dinitrogen oxidoreductase (ATP-hydrolyzing)

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00148
Domain description: Nitrogenase component 1 type Oxidoreductase
Occurring in:
  1. Nitrogenase molybdenum-iron protein alpha chain
  2. Nitrogenase molybdenum-iron protein beta chain
The deposited structure of PDB entry 1m1n contains 4 copies of Pfam domain PF00148 (Nitrogenase component 1 type Oxidoreductase) in Nitrogenase molybdenum-iron protein alpha chain. Showing 1 copy in chain A.
The deposited structure of PDB entry 1m1n contains 4 copies of Pfam domain PF00148 (Nitrogenase component 1 type Oxidoreductase) in Nitrogenase molybdenum-iron protein beta chain. Showing 1 copy in chain B.

PF11844
Domain description: Domain of unknown function (DUF3364)
Occurring in:
  1. Nitrogenase molybdenum-iron protein beta chain
The deposited structure of PDB entry 1m1n contains 4 copies of Pfam domain PF11844 (Domain of unknown function (DUF3364)) in Nitrogenase molybdenum-iron protein beta chain. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR000318
Domain description: Nitrogenase component 1, conserved site
Occurring in:
  1. Nitrogenase molybdenum-iron protein alpha chain
  2. Nitrogenase molybdenum-iron protein beta chain
IPR000510
Domain description: Nitrogenase/oxidoreductase, component 1
Occurring in:
  1. Nitrogenase molybdenum-iron protein alpha chain
  2. Nitrogenase molybdenum-iron protein beta chain
IPR005972
Domain description: Nitrogenase molybdenum-iron protein alpha chain
Occurring in:
  1. Nitrogenase molybdenum-iron protein alpha chain
IPR010143
Domain description: Nitrogenase component 1, alpha chain
Occurring in:
  1. Nitrogenase molybdenum-iron protein alpha chain
IPR024564
Domain description: Nitrogenase molybdenum-iron protein beta chain, N-terminal
Occurring in:
  1. Nitrogenase molybdenum-iron protein beta chain
IPR005976
Domain description: Nitrogenase molybdenum-iron protein beta chain
Occurring in:
  1. Nitrogenase molybdenum-iron protein beta chain

Structure domains

CATH CATH domains
3.40.50.1980
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Nitrogenase molybdenum iron protein domain
Occurring in:
  1. Nitrogenase molybdenum-iron protein alpha chain
  2. Nitrogenase molybdenum-iron protein beta chain
The deposited structure of PDB entry 1m1n contains 12 copies of CATH domain 3.40.50.1980 (Rossmann fold) in Nitrogenase molybdenum-iron protein alpha chain. Showing 3 copies in chain A.
The deposited structure of PDB entry 1m1n contains 12 copies of CATH domain 3.40.50.1980 (Rossmann fold) in Nitrogenase molybdenum-iron protein beta chain. Showing 3 copies in chain B.
1.20.89.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Nitrogenase Molybdenum-iron Protein, subunit B; domain 4
Homology: Nitrogenase Molybdenum-iron Protein, subunit B, domain 4
Occurring in:
  1. Nitrogenase molybdenum-iron protein beta chain
The deposited structure of PDB entry 1m1n contains 4 copies of CATH domain 1.20.89.10 (Nitrogenase Molybdenum-iron Protein, subunit B; domain 4) in Nitrogenase molybdenum-iron protein beta chain. Showing 1 copy in chain B.
SCOP SCOP annotation
53816
Class: Alpha and beta proteins (a/b)
Fold: Chelatase-like
Superfamily: "Helical backbone" metal receptor
Occurring in:
  1. Nitrogenase molybdenum-iron protein alpha chain
  2. Nitrogenase molybdenum-iron protein beta chain
The deposited structure of PDB entry 1m1n contains 4 copies of SCOP domain 53816 (Nitrogenase iron-molybdenum protein) in Nitrogenase molybdenum-iron protein alpha chain. Showing 1 copy in chain A.
The deposited structure of PDB entry 1m1n contains 4 copies of SCOP domain 53816 (Nitrogenase iron-molybdenum protein) in Nitrogenase molybdenum-iron protein beta chain. Showing 1 copy in chain B.

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