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Refinement of BMP7 crystal structure

X-ray diffraction
2Å resolution
PDB entry 1lxi coloured by chain, front view.
PDB entry 1lxi coloured by chain, side view.
PDB entry 1lxi coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Bone morphogenetic protein 7
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Multimeric state: homo dimer
Accessible surface area: 12177.61 Å2
Buried surface area: 3173.58 Å2
Dissociation area: 1,211.68 Å2
Dissociation energy (ΔGdiss): 18.4 kcal/mol
Dissociation entropy (TΔSdiss): 11.93 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-148281

Macromolecules

Bone morphogenetic protein 7
Chain: A
Length: 139 amino acids
Theoretical weight: 15.7 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P18075 (Residues: 293-431; Coverage: 35%)
Gene names: BMP7, OP1
Pfam: Transforming growth factor beta like domain
InterPro:
CATH: Cystine-knot cytokines
SCOP: Transforming growth factor (TGF)-beta
Bone morphogenetic protein 7 in PDB entry 1lxi, assembly 1, front view.
Bone morphogenetic protein 7 in PDB entry 1lxi, assembly 1, side view.
Bone morphogenetic protein 7 in PDB entry 1lxi, assembly 1, top view.
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