› 1luz

X-ray diffraction
1.8Å resolution

Crystal Structure of the K3L Protein From Vaccinia Virus (Wisconsin Strain)

Released:
DOI: 10.2210/pdb1luz/pdb
PDB entry 1luz coloured by chain, front view.
PDB entry 1luz coloured by chain, side view.
PDB entry 1luz coloured by chain, top view.
Source organism: Vaccinia virus WR
Primary publication:
X-ray crystal structure and functional analysis of vaccinia virus K3L reveals molecular determinants for PKR subversion and substrate recognition.
Dar AC, Sicheri F
Mol Cell 10 295-305 (2002)
PMID: 12191475

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148360 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein K3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 88 amino acids
Theoretical weight: 10.72 KDa
Source organism: Vaccinia virus WR
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P18378 (Residues: 1-88; Coverage: 100%)
Gene names: K2L, K3L, VACWR034
Sequence domains: S1 RNA binding domain
Structure domains: Nucleic acid-binding proteins

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 6 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-C
Spacegroup: C2
Unit cell:
a: 73.119Å b: 49.58Å c: 59.938Å
α: 90° β: 100.69° γ: 90°
R-values:
R R work R free
0.232 0.232 0.256
Expression system: Escherichia coli BL21

Quick links

Citations

18 review citations

The dsRNA binding protein family: critical roles, diverse cellular functions.
Saunders et al. (2003)
17 more

11 mentions without citation

How vaccinia virus has evolved to subvert the host immune response.
Bahar et al. (2011)
10 more