X-ray diffraction
2.5Å resolution

Crystal Structure of the Beta-catenin/ICAT Complex


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Catenin beta-1 Chain: A
Molecule details ›
Chain: A
Length: 514 amino acids
Theoretical weight: 56.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P35222 (Residues: 150-663; Coverage: 66%)
Gene names: CTNNB, CTNNB1, OK/SW-cl.35, PRO2286
Sequence domains: Armadillo/beta-catenin-like repeat
Structure domains: Leucine-rich Repeat Variant
Beta-catenin-interacting protein 1 Chain: B
Molecule details ›
Chain: B
Length: 75 amino acids
Theoretical weight: 8.43 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
  • Canonical: Q9JJN6 (Residues: 1-75; Coverage: 93%)
Gene names: Catnbip1, Ctnnbip1, Icat
Structure domains: Beta-catenin-interacting ICAT

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21212
Unit cell:
a: 95.174Å b: 98.504Å c: 86.486Å
α: 90° β: 90° γ: 90°
R R work R free
0.215 0.21 0.255
Expression system: Escherichia coli