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X-ray diffraction
3Å resolution

CRYSTAL STRUCTURE OF PHOSPHOGLYCERATE KINASE FROM PLASMODIUM FALCIPARUM, IN THE OPEN CONFORMATION

Released:
DOI: 10.2210/pdb1ltk/pdb
PDB 1ltk coloured by chain and viewed from the front.
PDB 1ltk coloured by chain and viewed from the side.
PDB 1ltk coloured by chain and viewed from the top.
Source organism: Plasmodium falciparum
Entry authors: Chattopadhyay D, Pal B, Smith CD

Function and Biology Details

Reaction catalysed: 
ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphoglycerate kinase Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 425 amino acids
Theoretical weight: 47.02 KDa
Source organism: Plasmodium falciparum
Expression system: Escherichia coli
UniProt:
  • Canonical: P27362 (Residues: 2-416; Coverage: 100%)
Gene names: PFI1105w, PGK
Sequence domains: Phosphoglycerate kinase
Structure domains: Phosphoglycerate kinase, N-terminal domain

Ligands and Environments

3 bound ligands:
Ligand SO4 3 x SO4
Ligand AMP 3 x AMP
Ligand GOL 1 x GOL
1 modified residue:
Ligand MSE 27 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: I222
Unit cell:
a: 119.03Å b: 147.61Å c: 206.49Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.284 0.208 0.258
Expression system: Escherichia coli

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