X-ray diffraction
2.7Å resolution

Crystal Structure of the Complex between Rabbit Cytosolic Serine Hydroxymethyltransferase and TriGlu-5-formyl-tetrahydrofolate


Function and Biology Details

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Serine hydroxymethyltransferase, cytosolic Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 483 amino acids
Theoretical weight: 52.92 KDa
Source organism: Oryctolagus cuniculus
Expression system: Escherichia coli
  • Canonical: P07511 (Residues: 2-484; Coverage: 100%)
Gene name: SHMT1
Sequence domains: Serine hydroxymethyltransferase
Structure domains:

Ligands and Environments

Cofactor: Ligand PLP 4 x PLP
3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P41
Unit cell:
a: 114.084Å b: 114.084Å c: 156.719Å
α: 90° β: 90° γ: 90°
R R work R free
0.22 0.22 0.294
Expression system: Escherichia coli