1lpa

X-ray diffraction
3.04Å resolution

INTERFACIAL ACTIVATION OF THE LIPASE-PROCOLIPASE COMPLEX BY MIXED MICELLES REVEALED BY X-RAY CRYSTALLOGRAPHY

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Colipase Chain: A
Molecule details ›
Chain: A
Length: 95 amino acids
Theoretical weight: 10.35 KDa
Source organism: Sus scrofa
Expression system: Not provided
UniProt:
  • Canonical: P02703 (Residues: 18-110; Coverage: 98%)
Gene name: CLPS
Sequence domains:
Structure domains: Lipase, subunit A
Pancreatic triacylglycerol lipase Chain: B
Molecule details ›
Chain: B
Length: 449 amino acids
Theoretical weight: 49.57 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P16233 (Residues: 17-465; Coverage: 100%)
Gene name: PNLIP
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P42212
Unit cell:
a: 133.4Å b: 133.4Å c: 92.6Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.186 not available
Expression system: Not provided