1lnu

X-ray diffraction
2.5Å resolution

CRYSTAL STRUCTURE OF CLASS II MHC MOLECULE IAb BOUND TO EALPHA3K PEPTIDE

Released:
Source organism: Mus musculus
Entry authors: Liu X, Dai S, Crawford F, Fruge R, Marrack P, Kappler J

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
H-2 class II histocompatibility antigen, A-B alpha chain Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 182 amino acids
Theoretical weight: 20.6 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P14434 (Residues: 27-208; Coverage: 78%)
Gene name: H2-Aa
Sequence domains:
Structure domains:
H-2 class II histocompatibility antigen, A beta chain Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 217 amino acids
Theoretical weight: 24.94 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P14483 (Residues: 24-218; Coverage: 80%)
Gene names: H2-Ab1, H2-iabeta
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: P21
Unit cell:
a: 65.04Å b: 274.18Å c: 65.12Å
α: 90° β: 111.42° γ: 90°
R-values:
R R work R free
0.211 0.211 0.245
Expression systems:
  • Spodoptera frugiperda
  • Escherichia coli