› 1ln1

X-ray diffraction
2.4Å resolution

Crystal Structure of Human Phosphatidylcholine Transfer Protein in Complex with Dilinoleoylphosphatidylcholine

Released:
DOI: 10.2210/pdb1ln1/pdb
PDB entry 1ln1 coloured by chain, front view.
PDB entry 1ln1 coloured by chain, side view.
PDB entry 1ln1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of human phosphatidylcholine transfer protein in complex with its ligand.
Roderick SL, Chan WW, Agate DS, Olsen LR, Vetting MW, Rajashankar KR, Cohen DE
Nat Struct Biol 9 507-11 (2002)
PMID: 12055623

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193854 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylcholine transfer protein Chain: A
Molecule details ›
Chain: A
Length: 214 amino acids
Theoretical weight: 24.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UKL6 (Residues: 1-214; Coverage: 100%)
Gene names: PCTP, STARD2
Sequence domains: START domain
Structure domains: Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 4

Ligands and Environments

1 bound ligand:
Ligand DLP 1 x DLP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X9A
Spacegroup: I422
Unit cell:
a: 133.3Å b: 133.3Å c: 83Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.237 0.234 0.296
Expression system: Escherichia coli

Quick links

Citations

30 review citations

Early steps in steroidogenesis: intracellular cholesterol trafficking.
Miller et al. (2011)
29 more

27 mentions without citation

Mechanisms of Non-Vesicular Exchange of Lipids at Membrane Contact Sites: Of Shuttles, Tunnels and, Funnels.
Egea PF. (2021)
26 more