X-ray diffraction
3Å resolution

Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure


Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Desmoplakin Chains: A, B
Molecule details ›
Chains: A, B
Length: 248 amino acids
Theoretical weight: 27.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P15924 (Residues: 2209-2456; Coverage: 9%)
Gene name: DSP
Sequence domains: Plectin repeat
Structure domains: Plakin repeat

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P21
Unit cell:
a: 48.293Å b: 99.773Å c: 51.687Å
α: 90° β: 97.58° γ: 90°
R R work R free
0.249 0.249 0.296
Expression system: Escherichia coli