Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-134654 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Interleukin-10
Molecule details ›
Chains: A, B
Length: 160 amino acids
Theoretical weight: 18.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
Sequence domains: Interleukin 10
Structure domains: Growth Hormone; Chain: A;
Length: 160 amino acids
Theoretical weight: 18.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
- Canonical:
P22301 (Residues: 25-134, 135-178; Coverage: 96%)
Sequence domains: Interleukin 10
Structure domains: Growth Hormone; Chain: A;
Ig kappa chain C region, B allele
Molecule details ›
Chains: L, M
Length: 210 amino acids
Theoretical weight: 22.79 KDa
Source organism: Rattus norvegicus
UniProt:
Structure domains: Immunoglobulins
Length: 210 amino acids
Theoretical weight: 22.79 KDa
Source organism: Rattus norvegicus
UniProt:
- Canonical: P01835 (Residues: 1-103; Coverage: 97%)
Structure domains: Immunoglobulins
Ig gamma-1 chain C region
Molecule details ›
Chains: H, I
Length: 219 amino acids
Theoretical weight: 23.53 KDa
Source organism: Rattus norvegicus
UniProt:
Structure domains: Immunoglobulins
Length: 219 amino acids
Theoretical weight: 23.53 KDa
Source organism: Rattus norvegicus
UniProt:
- Canonical: P20759 (Residues: 1-100; Coverage: 31%)
Structure domains: Immunoglobulins
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
SSRL BEAMLINE BL9-1
Spacegroup:
P21
Expression system: Escherichia coli BL21
