Structure analysis

1.8A Resolution Structure of Latent Plasminogen Activator Inhibitor-1(PAI-1)

X-ray diffraction
1.8Å resolution
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: monomeric
Accessible surface area: 16300 Å2
Buried surface area: 900 Å2
Dissociation area: 100 Å2
Dissociation energy (ΔGdiss): -3 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Interface energy (ΔGint): 9 kcal/mol
Symmetry number: 1

Macromolecules

Chain: A
Length: 379 amino acids
Theoretical weight: 42.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P05121 (Residues: 24-402; Coverage: 100%)
Gene names: PAI1, PLANH1, SERPINE1
Pfam: Serpin (serine protease inhibitor)
InterPro:
CATH:
SCOP: Serpins

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