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1.8A Resolution Structure of Latent Plasminogen Activator Inhibitor-1(PAI-1)

X-ray diffraction
1.8Å resolution
PDB entry 1lj5 coloured by chain, front view.
PDB entry 1lj5 coloured by chain, side view.
PDB entry 1lj5 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Plasminogen activator inhibitor 1
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Multimeric state: monomeric
Accessible surface area: 16390.98 Å2
Buried surface area: 888.27 Å2
Dissociation area: 84.42 Å2
Dissociation energy (ΔGdiss): -3.15 kcal/mol
Dissociation entropy (TΔSdiss): 0.09 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-138523

Macromolecules

Plasminogen activator inhibitor 1
Chain: A
Length: 379 amino acids
Theoretical weight: 42.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P05121 (Residues: 24-402; Coverage: 100%)
Gene names: PAI1, PLANH1, SERPINE1
Pfam: Serpin (serine protease inhibitor)
InterPro:
CATH:
SCOP: Serpins
Plasminogen activator inhibitor 1 in PDB entry 1lj5, assembly 1, front view.
Plasminogen activator inhibitor 1 in PDB entry 1lj5, assembly 1, side view.
Plasminogen activator inhibitor 1 in PDB entry 1lj5, assembly 1, top view.
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